biostudies-literatureHan DNHLBI NIH HHS309-319https://www.ebi.ac.uk/biostudies/studies/S-EPMC8792800biostudies-literatureUnknown7(3)<h4>Importance</h4>Distinct plaque locations and vessel geometric features predispose to altered coronary flow hemodynamics. The association between these lesion-level characteristics assessed by coronary computed tomographic angiography (CCTA) and risk of future acute coronary syndrome (ACS) is unknown.<h4>Objective</h4>To examine whether CCTA-derived adverse geometric characteristics (AGCs) of coronary lesions describing location and vessel geometry add to plaque morphology and burden for identifying culprit lesion precursors associated with future ACS.<h4>Design, setting, and participants</h4>This substudy of ICONIC (Incident Coronary Syndromes Identified by Computed Tomography), a multicenter nested case-control cohort study, included patients with ACS and a culprit lesion precursor idJAMA cardiologyAssociation of Plaque Location and Vessel Geometry Determined by Coronary Computed Tomographic Angiography With Future Acute Coronary Syndrome-Causing Culprit Lesions.PMC8792800R01 HL151266R01 HL148787Van Rosendael AAndreini DCademartiri FLu YAl'Aref SJLin FYStone PHChinnaiyan KBudoff MJBerman DSVillines TCDanad IConte EKim YJMarques HSlomka PJLee JHPlank FGransar HChow BJWKwan ACTzolos Ede Araujo Goncalves PAl-Mallah MHLee SEVirmani RBax JJMaffei EAchenbach SKuronuma KMin JKKlein EDey DLin AYoon YEHadamitzky MNarula JChang HJBaskaran LShaw LJSamady HFeuchtner GPontone GHan DCury RCLeipsic JAfalseAssociation of Plaque Location and Vessel Geometry Determined by Coronary Computed Tomographic Angiography With Future Acute Coronary Syndrome-Causing Culprit Lesions.<h4>Importance</h4>Distinct plaque locations and vessel geometric features predispose to altered coronary flow hemodynamics. The association between these lesion-level characteristics assessed by coronary computed tomographic angiography (CCTA) and risk of future acute coronary syndrome (ACS) is unknown.<h4>Objective</h4>To examine whether CCTA-derived adverse geometric characteristics (AGCs) of coronary lesions describing location and vessel geometry add to plaque morphology and burden for identifying culprit lesion precursors associated with future ACS.<h4>Design, setting, and participants</h4>This substudy of ICONIC (Incident Coronary Syndromes Identified by Computed Tomography), a multicenter nested case-control cohort study, included patients with ACS and a culprit lesion precursor id2022-01-01T00:00:00Z2022 Mar2025-04-04T13:36:34.698Z2025-04-04T13:36:34.698ZS-EPMC87928003508058710.1001/jamacardio.2021.5705