{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Vallcaneras S"],"funding":["Faculty of Medicine, McGill University","Universidad Nacional de San Luis"],"pagination":["19"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8793209"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(1)"],"pubmed_abstract":["<h4>Background</h4>Nitric oxide and GnRH are biological factors that participate in the regulation of reproductive functions. To our knowledge, there are no studies that link NO and GnRH in the sympathetic ganglia. Thus, the aim of the present work was to investigate the influence of NO on GnRH release from the coeliac ganglion and its effect on luteal regression at the end of pregnancy in the rat.<h4>Methods</h4>The ex vivo system composed by the coeliac ganglion, the superior ovarian nerve, and the ovary of rats on day 21 of pregnancy was incubated for 180 min with the addition, into the ganglionic compartment, of L-N<sup>G</sup>-nitro arginine methyl ester (L-NAME), a non-selective NO synthase inhibitor. The control group consisted in untreated organ systems.<h4>Results</h4>The addition"],"journal":["Reproductive biology and endocrinology : RB&E"],"pubmed_title":["Interplay between nitric oxide and gonadotrophin-releasing hormone in the neuromodulation of the corpus luteum during late pregnancy in the rat."],"pmcid":["PMC8793209"],"funding_grant_id":["Fund 172858 Department of Pathology","PROICO 2-2916 UNSL"],"pubmed_authors":["Morales L","Telleria CM","Fernandez M","Casais M","Delsouc MB","Ramirez D","Vallcaneras S","Filippa V"],"additional_accession":[]},"is_claimable":false,"name":"Interplay between nitric oxide and gonadotrophin-releasing hormone in the neuromodulation of the corpus luteum during late pregnancy in the rat.","description":"<h4>Background</h4>Nitric oxide and GnRH are biological factors that participate in the regulation of reproductive functions. To our knowledge, there are no studies that link NO and GnRH in the sympathetic ganglia. Thus, the aim of the present work was to investigate the influence of NO on GnRH release from the coeliac ganglion and its effect on luteal regression at the end of pregnancy in the rat.<h4>Methods</h4>The ex vivo system composed by the coeliac ganglion, the superior ovarian nerve, and the ovary of rats on day 21 of pregnancy was incubated for 180 min with the addition, into the ganglionic compartment, of L-N<sup>G</sup>-nitro arginine methyl ester (L-NAME), a non-selective NO synthase inhibitor. The control group consisted in untreated organ systems.<h4>Results</h4>The addition","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jan","modification":"2026-07-09T11:58:57.841Z","creation":"2025-05-29T16:07:03.167Z"},"accession":"S-EPMC8793209","cross_references":{"pubmed":["35081973"],"doi":["10.1186/s12958-022-00894-6"]}}