{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Manhard MK"],"funding":["NIBIB NIH HHS","NCRR NIH HHS","NIMH NIH HHS"],"pagination":["866-880"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8793364"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["86(2)"],"pubmed_abstract":["<h4>Purpose</h4>Brain imaging exams typically take 10-20 min and involve multiple sequential acquisitions. A low-distortion whole-brain echo planar imaging (EPI)-based approach was developed to efficiently encode multiple contrasts in one acquisition, allowing for calculation of quantitative parameter maps and synthetic contrast-weighted images.<h4>Methods</h4>Inversion prepared spin- and gradient-echo EPI was developed with slice-order shuffling across measurements for efficient acquisition with T<sub>1</sub> , T<sub>2</sub> , and T2∗ weighting. A dictionary-matching approach was used to fit the images to quantitative parameter maps, which in turn were used to create synthetic weighted images with typical clinical contrasts. Dynamic slice-optimized multi-coil shimming with a B<sub>0</sub> shim array was used to reduce B<sub>0</sub> inhomogeneity and, therefore, image distortion by >50%. Multi-shot EPI was also implemented to minimize distortion and blurring while enabling high in-plane resolution. A low-rank reconstruction approach was used to mitigate errors from shot-to-shot phase variation.<h4>Results</h4>The slice-optimized shimming approach was combined with in-plane parallel-imaging acceleration of 4× to enable single-shot EPI with more than eight-fold distortion reduction. The proposed sequence efficiently obtained 40 contrasts across the whole-brain in just over 1 min at 1.2 × 1.2 × 3 mm resolution. The multi-shot variant of the sequence achieved higher in-plane resolution of 1 × 1 × 4 mm with good image quality in 4 min. Derived quantitative maps showed comparable values to conventional mapping methods.<h4>Conclusion</h4>The approach allows fast whole-brain imaging with quantitative parameter maps and synthetic weighted contrasts. The slice-optimized multi-coil shimming and multi-shot reconstruction approaches result in minimal EPI distortion, giving the sequence the potential to be used in rapid screening applications."],"journal":["Magnetic resonance in medicine"],"pubmed_title":["A multi-inversion multi-echo spin and gradient echo echo planar imaging sequence with low image distortion for rapid quantitative parameter mapping and synthetic image contrasts."],"pmcid":["PMC8793364"],"funding_grant_id":["S10 RR019254","S10 RR023401","P41 EB015896","R01 EB020613","R01 MH116173","S10 RR019307","U01 EB025162","F32 EB026304","R01 EB019437","S10 RR023043"],"pubmed_authors":["Manhard MK","van den Boomen M","Polimeni J","Setsompop K","Stockmann J","Fair M","Liao C","Han S","Bilgic B","Park D"],"additional_accession":[]},"is_claimable":false,"name":"A multi-inversion multi-echo spin and gradient echo echo planar imaging sequence with low image distortion for rapid quantitative parameter mapping and synthetic image contrasts.","description":"<h4>Purpose</h4>Brain imaging exams typically take 10-20 min and involve multiple sequential acquisitions. A low-distortion whole-brain echo planar imaging (EPI)-based approach was developed to efficiently encode multiple contrasts in one acquisition, allowing for calculation of quantitative parameter maps and synthetic contrast-weighted images.<h4>Methods</h4>Inversion prepared spin- and gradient-echo EPI was developed with slice-order shuffling across measurements for efficient acquisition with T<sub>1</sub> , T<sub>2</sub> , and T2∗ weighting. A dictionary-matching approach was used to fit the images to quantitative parameter maps, which in turn were used to create synthetic weighted images with typical clinical contrasts. Dynamic slice-optimized multi-coil shimming with a B<sub>0</sub> shim array was used to reduce B<sub>0</sub> inhomogeneity and, therefore, image distortion by >50%. Multi-shot EPI was also implemented to minimize distortion and blurring while enabling high in-plane resolution. A low-rank reconstruction approach was used to mitigate errors from shot-to-shot phase variation.<h4>Results</h4>The slice-optimized shimming approach was combined with in-plane parallel-imaging acceleration of 4× to enable single-shot EPI with more than eight-fold distortion reduction. The proposed sequence efficiently obtained 40 contrasts across the whole-brain in just over 1 min at 1.2 × 1.2 × 3 mm resolution. The multi-shot variant of the sequence achieved higher in-plane resolution of 1 × 1 × 4 mm with good image quality in 4 min. Derived quantitative maps showed comparable values to conventional mapping methods.<h4>Conclusion</h4>The approach allows fast whole-brain imaging with quantitative parameter maps and synthetic weighted contrasts. The slice-optimized multi-coil shimming and multi-shot reconstruction approaches result in minimal EPI distortion, giving the sequence the potential to be used in rapid screening applications.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Aug","modification":"2025-04-19T22:39:29.807Z","creation":"2025-02-19T04:06:46.929Z"},"accession":"S-EPMC8793364","cross_references":{"pubmed":["33764563"],"doi":["10.1002/mrm.28761"]}}