{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["BEAR-MOON Design Group"],"funding":["NIAMS NIH HHS"],"pagination":["23259671211065447"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8793429"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(1)"],"pubmed_abstract":["<h4>Background</h4>BEAR (bridge-enhanced anterior cruciate ligament [ACL] restoration), a paradigm-shifting technology to heal midsubstance ACL tears, has been demonstrated to be effective in a single-center 2:1 randomized controlled trial (RCT) versus hamstring ACL reconstruction. Widespread dissemination of BEAR into clinical practice should also be informed by a multicenter RCT to demonstrate exportability and compare efficacy with bone--patellar tendon-bone (BPTB) ACL reconstruction, another clinically standard treatment.<h4>Purpose</h4>To present the design and initial preparation of a multicenter RCT of BEAR versus BPTB ACL reconstruction (the BEAR: Multicenter Orthopaedic Outcomes Network [BEAR-MOON] trial). Design and analytic issues in planning the complex BEAR-MOON trial, involvi"],"journal":["Orthopaedic journal of sports medicine"],"pubmed_title":["Design Features and Rationale of the BEAR-MOON (Bridge-Enhanced ACL Restoration Multicenter Orthopaedic Outcomes Network) Randomized Clinical Trial."],"pmcid":["PMC8793429"],"funding_grant_id":["R01 AR074131"],"pubmed_authors":["Beck GJ","BEAR-MOON Design Group","Winalski CS","Wright R","Yalcin S","Kaeding C","McErlean E","Spindler KP","Magnussen R","Kriz P","Owens BD","Strnad G","Melgaard C","Jones MH","Hulstyn MJ","Saluan P","Calbrese G","Fleming BC","Cox CL","Fitch R","Flanigan D","Imrey PB","Katz JN","Fadale PD","Farrow L"],"additional_accession":[]},"is_claimable":false,"name":"Design Features and Rationale of the BEAR-MOON (Bridge-Enhanced ACL Restoration Multicenter Orthopaedic Outcomes Network) Randomized Clinical Trial.","description":"<h4>Background</h4>BEAR (bridge-enhanced anterior cruciate ligament [ACL] restoration), a paradigm-shifting technology to heal midsubstance ACL tears, has been demonstrated to be effective in a single-center 2:1 randomized controlled trial (RCT) versus hamstring ACL reconstruction. Widespread dissemination of BEAR into clinical practice should also be informed by a multicenter RCT to demonstrate exportability and compare efficacy with bone--patellar tendon-bone (BPTB) ACL reconstruction, another clinically standard treatment.<h4>Purpose</h4>To present the design and initial preparation of a multicenter RCT of BEAR versus BPTB ACL reconstruction (the BEAR: Multicenter Orthopaedic Outcomes Network [BEAR-MOON] trial). Design and analytic issues in planning the complex BEAR-MOON trial, involvi","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jan","modification":"2026-05-09T06:04:08.13Z","creation":"2022-02-11T15:39:48.564Z"},"accession":"S-EPMC8793429","cross_references":{"pubmed":["35097143"],"doi":["10.1177/23259671211065447"]}}