biostudies-literatureBEAR-MOON Design GroupNIAMS NIH HHS23259671211065447https://www.ebi.ac.uk/biostudies/studies/S-EPMC8793429biostudies-literatureUnknown10(1)<h4>Background</h4>BEAR (bridge-enhanced anterior cruciate ligament [ACL] restoration), a paradigm-shifting technology to heal midsubstance ACL tears, has been demonstrated to be effective in a single-center 2:1 randomized controlled trial (RCT) versus hamstring ACL reconstruction. Widespread dissemination of BEAR into clinical practice should also be informed by a multicenter RCT to demonstrate exportability and compare efficacy with bone--patellar tendon-bone (BPTB) ACL reconstruction, another clinically standard treatment.<h4>Purpose</h4>To present the design and initial preparation of a multicenter RCT of BEAR versus BPTB ACL reconstruction (the BEAR: Multicenter Orthopaedic Outcomes Network [BEAR-MOON] trial). Design and analytic issues in planning the complex BEAR-MOON trial, involviOrthopaedic journal of sports medicineDesign Features and Rationale of the BEAR-MOON (Bridge-Enhanced ACL Restoration Multicenter Orthopaedic Outcomes Network) Randomized Clinical Trial.PMC8793429R01 AR074131Beck GJBEAR-MOON Design GroupWinalski CSWright RYalcin SKaeding CMcErlean ESpindler KPMagnussen RKriz POwens BDStrnad GMelgaard CJones MHHulstyn MJSaluan PCalbrese GFleming BCCox CLFitch RFlanigan DImrey PBKatz JNFadale PDFarrow LfalseDesign Features and Rationale of the BEAR-MOON (Bridge-Enhanced ACL Restoration Multicenter Orthopaedic Outcomes Network) Randomized Clinical Trial.<h4>Background</h4>BEAR (bridge-enhanced anterior cruciate ligament [ACL] restoration), a paradigm-shifting technology to heal midsubstance ACL tears, has been demonstrated to be effective in a single-center 2:1 randomized controlled trial (RCT) versus hamstring ACL reconstruction. Widespread dissemination of BEAR into clinical practice should also be informed by a multicenter RCT to demonstrate exportability and compare efficacy with bone--patellar tendon-bone (BPTB) ACL reconstruction, another clinically standard treatment.<h4>Purpose</h4>To present the design and initial preparation of a multicenter RCT of BEAR versus BPTB ACL reconstruction (the BEAR: Multicenter Orthopaedic Outcomes Network [BEAR-MOON] trial). Design and analytic issues in planning the complex BEAR-MOON trial, involvi2022-01-01T00:00:00Z2022 Jan2026-05-09T06:04:08.13Z2022-02-11T15:39:48.564ZS-EPMC87934293509714310.1177/23259671211065447