{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["McGrath J"],"funding":["Intramural NIH HHS","NIDCD NIH HHS","National Institute on Deafness and Other Communication Disorders"],"pagination":["1141-1153.e7"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8793668"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["31(6)"],"pubmed_abstract":["Stereocilia on auditory sensory cells are actin-based protrusions that mechanotransduce sound into an electrical signal. These stereocilia are arranged into a bundle with three rows of increasing length to form a staircase-like morphology that is required for hearing. Stereocilia in the shorter rows, but not the tallest row, are mechanotransducing because they have force-sensitive channels localized at their tips. The onset of mechanotransduction during mouse postnatal development refines stereocilia length and width. However, it is unclear how actin is differentially regulated between stereocilia in the tallest row of the bundle and the shorter, mechanotransducing rows. Here, we show actin turnover is increased at the tips of mechanotransducing stereocilia during bundle maturation. Corres"],"journal":["Current biology : CB"],"pubmed_title":["Actin at stereocilia tips is regulated by mechanotransduction and ADF/cofilin."],"pmcid":["PMC8793668"],"funding_grant_id":["R01 DC015495","T32 DC000039","R01 DC018827","Z01 DC000039"],"pubmed_authors":["Faaborg-Andersen CC","Li J","Zhao B","Liao X","McGrath J","Berbari NF","Perrin BJ","Barzik M","Friedman TB","Balakrishnan L","Tung CY","Belyantseva IA","Roy P","Bird JE","Chakraborty O"],"additional_accession":[]},"is_claimable":false,"name":"Actin at stereocilia tips is regulated by mechanotransduction and ADF/cofilin.","description":"Stereocilia on auditory sensory cells are actin-based protrusions that mechanotransduce sound into an electrical signal. These stereocilia are arranged into a bundle with three rows of increasing length to form a staircase-like morphology that is required for hearing. Stereocilia in the shorter rows, but not the tallest row, are mechanotransducing because they have force-sensitive channels localized at their tips. The onset of mechanotransduction during mouse postnatal development refines stereocilia length and width. However, it is unclear how actin is differentially regulated between stereocilia in the tallest row of the bundle and the shorter, mechanotransducing rows. Here, we show actin turnover is increased at the tips of mechanotransducing stereocilia during bundle maturation. Corres","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2026-05-31T04:00:09.037Z","creation":"2025-04-04T19:30:40.27Z"},"accession":"S-EPMC8793668","cross_references":{"pubmed":["33400922"],"doi":["10.1016/j.cub.2020.12.006"]}}