{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["GBD 2019 Dementia Collaborators"],"funding":["NIA NIH HHS","FIC NIH HHS","Medical Research Council","NHGRI NIH HHS"],"pagination":["286-296"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8794050"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["55(4)"],"pubmed_abstract":["<h4>Background</h4>In light of the increasing trend in the global number of individuals affected by dementia and the lack of any available disease-modifying therapies, it is necessary to fully understand and quantify the global burden of dementia. This work aimed to estimate the proportion of dementia due to Down syndrome, Parkinson's disease, clinical stroke, and traumatic brain injury (TBI), globally and by world region, in order to better understand the contribution of clinical diseases to dementia prevalence.<h4>Methods</h4>Through literature review, we obtained data on the relative risk of dementia with each condition and estimated relative risks by age using a Bayesian meta-regression tool. We then calculated population attributable fractions (PAFs), or the proportion of dementia att"],"journal":["Neuroepidemiology"],"pubmed_title":["The Burden of Dementia due to Down Syndrome, Parkinson's Disease, Stroke, and Traumatic Brain Injury: A Systematic Analysis for the Global Burden of Disease Study 2019."],"pmcid":["PMC8794050"],"funding_grant_id":["T32 AG000247","U01 HG010273","MR/T03355X/1","U01 AG016976","K43 TW010716","RF1 AG057531"],"pubmed_authors":["Doku PN","Leonardi M","Mohammed S","Baune BT","Manjunatha N","Cernigliaro A","Bijani A","Kalani R","Pazoki Toroudi H","Akinyemi RO","Mokdad AH","Panda-Jonas S","Pottoo FH","Shahid I","Rashedi V","Ilic MD","Singh JA","Yamagishi K","Ram P","Banach M","El-Jaafary SI","Vacante M","Yadollahpour A","Hwang BF","Hankey GJ","Yonemoto N","Logroscino G","Owolabi MO","Rezaei N","Shiri R","Szoeke CEI","Cerin E","Velazquez DZ","Tsegaye GW","Burugina Nagaraja S","Biswas A","LeGrand KE","Alipour V","Ostojic SM","Heidari G","Steinmetz JD","Brayne C","Golechha M","Iacoviello L","Ghashghaee A","Wang YP","Thakur B","Brenner H","Madhava Kunjathur S","Pourshams A","Barboza MA","Camera LA","Fischer F","Lorkowski S","Vu GT","Roshandel G","Patel UK","Amin HIM","Irvani SSN","Saylan M","Mossie TB","Abu-Gharbieh E","Ayano G","Naveed DM","Nguyen HLT","Burkart K","Koyanagi A","Tabares-Seisdedos R","Abd-Allah F","Nunez-Samudio V","Li B","Raggi A","Naimzada MD","Nichols E","Djalalinia S","Ilic IM","Chu DT","Cherbuin N","Karch A","Mehndiratta MM","Radfar A","Sha F","Castro-de-Araujo LFS","Zhang ZJ","Eskandarieh S","Yu C","Mohamed Ibrahim N","Valdez PR","Iso H","Burns RA","Mohapatra A","Ostroff SM","Dibaji Forooshani ZS","Silva JP","Islam MM","Nagel G","Pinheiro M","Kisa S","Boloor A","Wu C","Kumar M","Singhal D","Yano Y","Bhagavathula AS","Kukull WA","Murray CJL","Iwagami M","Mohammad Y","Dagnew B","Gialluisi A","Kisa A","Pham HQ","Hassan A","Jha RP","Robinson SR","Shigematsu M","Venketasubramanian N","Rana J","Hay SI","Vos T","Dang AK","Barker-Collo SL","Prada SI","Abdoli A","Rawaf DL","Ferrara P","Tovani-Palone MR","Fernandes E","Otstavnov N","Sattin D","Rezapour A","Schiavolin S","Sahraian MA","Baig AA","Diaz D","Filip I","Soheili A","Moradi G","Travillian RS","Nguyen CT","Meharie BG","Eskandari K","Landires I","Peterson CB","Sachdev PS","Househ M","Arabloo J","Nayak VC","Bhattacharyya K","Feigin VL","Otstavnov SS","Sawhney M","Biondi A","Alanezi FM","GBD 2019 Dementia Collaborators","Liu X","Usman MS","Shin JI","Westerman R","Tran BX","Kim YJ","Heidari-Soureshjani R","Shaikh MA","Rawaf S","Sahebkar A","Bolla SR","Gaidhane S","Haider MR","Olagunju AT","Choi JJ","Mondello S","Reinig N","Nguyen SH","Hamidi S","Hegazy MI","Romoli M","Rahim F","Carvalho F","Pathak M","Piradov MA","Siddiqi TJ","Gnedovskaya EV","Ilesanmi OS","Shaw DH","Kasa AS","Fereshtehnejad SM","Jonas JB","Pribadi DRA","Yeshitila YG","Jozwiak JJ"],"additional_accession":[]},"is_claimable":false,"name":"The Burden of Dementia due to Down Syndrome, Parkinson's Disease, Stroke, and Traumatic Brain Injury: A Systematic Analysis for the Global Burden of Disease Study 2019.","description":"<h4>Background</h4>In light of the increasing trend in the global number of individuals affected by dementia and the lack of any available disease-modifying therapies, it is necessary to fully understand and quantify the global burden of dementia. This work aimed to estimate the proportion of dementia due to Down syndrome, Parkinson's disease, clinical stroke, and traumatic brain injury (TBI), globally and by world region, in order to better understand the contribution of clinical diseases to dementia prevalence.<h4>Methods</h4>Through literature review, we obtained data on the relative risk of dementia with each condition and estimated relative risks by age using a Bayesian meta-regression tool. We then calculated population attributable fractions (PAFs), or the proportion of dementia att","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2026-06-04T03:31:21.709Z","creation":"2022-02-11T15:55:17.462Z"},"accession":"S-EPMC8794050","cross_references":{"pubmed":["34182555"],"doi":["10.1159/000515393"]}}