biostudies-literatureCui QNational Natural Science Foundation of China2413-2427https://www.ebi.ac.uk/biostudies/studies/S-EPMC8794528biostudies-literatureUnknown20(22)Among urological tumors, renal cell carcinoma (RCC) is the third-highest mortality rate tumor, and 20%-30% of RCC patients present with metastases at the time of diagnosis. While the treatment of RCC has been improved over the last few years, its mortality stays high. Y-box binding protein 1 (YBX1) is a well-known oncoprotein that has tumor-promoting functions. YBX1 is widely considered to be an attractive therapeutic target in cancer. To develop novel therapeutics to target YBX1, it is of great importance to understand how YBX1 is finely regulated in cancer. Our previous studies showed that YBX1 in RCC cells significantly promoted cell adhesion, migration, and invasion. However, the role of YBX1 in RCC cells apoptosis has not been reported. In this study, we investigated the effect of YBXCell cycle (Georgetown, Tex.)YBX1 knockdown induces renal cell carcinoma cell apoptosis via Kindlin-2.PMC8794528818720782197409481772945Yue DDu RGeng HWang CTian SLiu SWang YChen RCui QSubramanian SNiu YfalseYBX1 knockdown induces renal cell carcinoma cell apoptosis via Kindlin-2.Among urological tumors, renal cell carcinoma (RCC) is the third-highest mortality rate tumor, and 20%-30% of RCC patients present with metastases at the time of diagnosis. While the treatment of RCC has been improved over the last few years, its mortality stays high. Y-box binding protein 1 (YBX1) is a well-known oncoprotein that has tumor-promoting functions. YBX1 is widely considered to be an attractive therapeutic target in cancer. To develop novel therapeutics to target YBX1, it is of great importance to understand how YBX1 is finely regulated in cancer. Our previous studies showed that YBX1 in RCC cells significantly promoted cell adhesion, migration, and invasion. However, the role of YBX1 in RCC cells apoptosis has not been reported. In this study, we investigated the effect of YBX2021-01-01T00:00:00Z2021 Nov2025-04-03T21:29:54.056Z2025-04-03T21:29:54.056ZS-EPMC87945283470996610.1080/15384101.2021.1985771