{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Loeser RF"],"funding":["Arthritis Foundation","National Institute of Arthritis and Musculoskeletal and Skin Diseases","National Center for Advancing Translational Sciences","NCATS NIH HHS","NCCDPHP CDC HHS","Crohn's & Colitis Foundation of America","National Institute of Diabetes and Digestive and Kidney Diseases","NIH Office of the Director","Office of the Director, NIH","Centers for Disease Control and Prevention","NIDDK NIH HHS","NIAMS NIH HHS","NIH HHS","Nutrition Obesity Resource Core of the National Institute of Diabetes and Digestive and Kidney Diseases","CDC HHS"],"pagination":["227-236"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8795472"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["74(2)"],"pubmed_abstract":["<h4>Objective</h4>To test the hypothesis that an altered gut microbiota (dysbiosis) plays a role in obesity-associated osteoarthritis (OA).<h4>Methods</h4>Stool and blood samples were collected from 92 participants with a body mass index (BMI) ≥30 kg/m<sup>2</sup> , recruited from the Johnston County Osteoarthritis Project. OA patients (n = 50) had hand and knee OA (Kellgren/Lawrence [K/L] grade ≥2 or arthroplasty). Controls (n = 42) had no hand OA and a K/L grade of 0-1 for the knees. Compositional analysis of stool samples was carried out by 16S ribosomal RNA amplicon sequencing. Alpha- and beta-diversity and differences in taxa relative abundances were determined. Blood samples were used for multiplex cytokine analysis and measures of lipopolysaccharide (LPS) and LPS binding protein. Ge"],"journal":["Arthritis & rheumatology (Hoboken, N.J.)"],"pubmed_title":["Association of Increased Serum Lipopolysaccharide, But Not Microbial Dysbiosis, With Obesity-Related Osteoarthritis."],"pmcid":["PMC8795472"],"funding_grant_id":["UL1-TR-002489","P30 DK056350","P30-DK-034987","UL1 TR002489","P30-DK-056350","U01‐DP‐006266","P40 OD010995","U01-DP-006266","U01 DP006266","P40‐OD‐010995","P30‐DK‐056350","718285","P40-OD-010995","P30‐AR‐072580","P30 DK034987","UL1‐TR‐002489","P30-AR-072580","P30‐DK‐034987","P30 AR072580"],"pubmed_authors":["Arbeeva L","Jordan JM","Azcarate-Peril MA","Kelley K","Longobardi L","Renner JB","Carroll IM","Cui Y","Sartor RB","Sun S","Fodor AA","Nelson AE","Ulici V","Stewart DA","Sumner SJ","Loeser RF"],"additional_accession":[]},"is_claimable":false,"name":"Association of Increased Serum Lipopolysaccharide, But Not Microbial Dysbiosis, With Obesity-Related Osteoarthritis.","description":"<h4>Objective</h4>To test the hypothesis that an altered gut microbiota (dysbiosis) plays a role in obesity-associated osteoarthritis (OA).<h4>Methods</h4>Stool and blood samples were collected from 92 participants with a body mass index (BMI) ≥30 kg/m<sup>2</sup> , recruited from the Johnston County Osteoarthritis Project. OA patients (n = 50) had hand and knee OA (Kellgren/Lawrence [K/L] grade ≥2 or arthroplasty). Controls (n = 42) had no hand OA and a K/L grade of 0-1 for the knees. Compositional analysis of stool samples was carried out by 16S ribosomal RNA amplicon sequencing. Alpha- and beta-diversity and differences in taxa relative abundances were determined. Blood samples were used for multiplex cytokine analysis and measures of lipopolysaccharide (LPS) and LPS binding protein. Ge","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Feb","modification":"2025-04-05T09:03:13.597Z","creation":"2025-04-05T09:03:13.597Z"},"accession":"S-EPMC8795472","cross_references":{"pubmed":["34423918"],"doi":["10.1002/art.41955"]}}