{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tong LL"],"funding":["Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project","Key University Science Research Project of Jiangsu Province","Jiangsu Provincial Natural Science Foundation"],"pagination":["12"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8796560"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(1)"],"pubmed_abstract":["Background
Polysaccharides are important active ingredients in Ophiocordyceps gracilis with many physiological functions. It can be obtained from the submerged fermentation by the anamorph (Paraisaria dubia) of Ophiocordyceps gracilis. However, it was found that the mycelial pellets of Paraisaria dubia were dense and increased in volume in the process of fermentation, and the center of the pellets was autolysis due to the lack of nutrient delivery, which extremely reduced the yield of polysaccharides. Therefore, it is necessary to excavate a fermentation strategy based on morphological regulation for Paraisaria dubia to promote polysaccharides accumulation.Results
In this study, we developed a method for enhancing polysaccharides production by Paraisaria dubia using micropa"],"journal":["Microbial cell factories"],"pubmed_title":["Enhancement of polysaccharides production using microparticle enhanced technology by Paraisaria dubia."],"pmcid":["PMC8796560"],"funding_grant_id":["TSBICIP-PTJS-003-04","BK20200732","19KJB530012"],"pubmed_authors":["Wang M","Guo DS","Yuan L","Liu MZ","Yang QH","Mu XY","Wang Y","Du YH","Li JY","Tong LL","Wei SX"],"additional_accession":[]},"is_claimable":false,"name":"Enhancement of polysaccharides production using microparticle enhanced technology by Paraisaria dubia.","description":"Background
Polysaccharides are important active ingredients in Ophiocordyceps gracilis with many physiological functions. It can be obtained from the submerged fermentation by the anamorph (Paraisaria dubia) of Ophiocordyceps gracilis. However, it was found that the mycelial pellets of Paraisaria dubia were dense and increased in volume in the process of fermentation, and the center of the pellets was autolysis due to the lack of nutrient delivery, which extremely reduced the yield of polysaccharides. Therefore, it is necessary to excavate a fermentation strategy based on morphological regulation for Paraisaria dubia to promote polysaccharides accumulation.Results
In this study, we developed a method for enhancing polysaccharides production by Paraisaria dubia using micropa","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jan","modification":"2025-05-29T19:37:37.298Z","creation":"2025-05-29T19:37:37.298Z"},"accession":"S-EPMC8796560","cross_references":{"pubmed":["35090444"],"doi":["10.1186/s12934-021-01733-w"]}}