biostudies-literatureGammie JSNCATS NIH HHSDeutsches Zentrum für Herz-KreislaufforschungNational Heart, Lung, and Blood InstituteNHLBI NIH HHS327-339https://www.ebi.ac.uk/biostudies/studies/S-EPMC8796794biostudies-literatureUnknown386(4)<h4>Background</h4>Tricuspid regurgitation is common in patients with severe degenerative mitral regurgitation. However, the evidence base is insufficient to inform a decision about whether to perform tricuspid-valve repair during mitral-valve surgery in patients who have moderate tricuspid regurgitation or less-than-moderate regurgitation with annular dilatation.<h4>Methods</h4>We randomly assigned 401 patients who were undergoing mitral-valve surgery for degenerative mitral regurgitation to receive a procedure with or without tricuspid annuloplasty (TA). The primary 2-year end point was a composite of reoperation for tricuspid regurgitation, progression of tricuspid regurgitation by two grades from baseline or the presence of severe tricuspid regurgitation, or death.<h4>Results</h4>PatieThe New England journal of medicineConcomitant Tricuspid Repair in Patients with Degenerative Mitral Regurgitation.PMC8796794N/AU01 HL088942UM1 HL117924UL1 TR001863UM1 HL088955Hong-Zohlman SGlower DDobrev EMiller MAGervais NNelavelli LLane KPetty GPhelan DFagu ABirru HPingpoh CMoquete EGSiemienik AO'Gara PTPfannmuller BPossemato TScheida IRomano MAMathewson SDemal TBecher HVesom NSidhu SPellerin MDunagan BDobrev VBhave NYancy CWLeinberger TFisher TTreffalls JGayburn PAlborzi FSturgis LMcCarty DSantos MYe XBaer JBoileau CLala ADautel PHenri CEgerson DCrowe STyler DFrohwein SBloem CFunkat AKNwokocha JLa Haye ASonnabend SChu MWAIribarne ARosengart TCaouette MZimmer ERao VDixon DOKoksoy CGoldstein DO'Meara EBoyd JAl-Suqi MNavia JNunes AHCarias De Oliveira NWagner IBurke CGarcia MPonder COrsak JHripko AEl-Hamamsy IMinko Nnanga HAPadilla MLRoldan JSt Ivany AAccardi ECzerny MBalay CJordan JThoma MKnosalla CRobles Magna MScheumann JMancini DMLozano Ede la Penha CKrajewski ARorie MAntioga KSchlosser JCallihan TDoyle DMiller RAPerron JMaier TCasalinova SGroh MDeutsch OHaider WGallandt ADe Leon Castro LKari FACosta BLevitan RPickel DKalavrouziotis DSmedira NShah KGepty CPrince TBauer MLiang DGuo LBowdish MEPage PPage MBurris SMichler RSchonrath KDeSimone JTkebuchava SFleischman FBoulton BJMandzia JLDanis MSabick JMurkin JMSchaffler MJohnston DDyal SCook JWelsh STremblay HNeaton JDRahko PD'Alessandro DKothmeier FJeanmart HDesai MRose EAHan YMohammadi SBarilotti BSchneider CKrane MRodina VCrestanello JABasmadijian ADent JDeRose JWierup PDombrowski LNagendran JSher LSHolzhey DCosta SKandrac JRuel MWood MMcIntosh LSamad ZSiepe MConradi LPistillo VSoltesz EWarren SGhanta RLiubaoerjijin YBaker DSauve CRuckert YKron ILLuderer KBlumel VWoo YJPandit PDumont EAstaiza-Bedoya GFalk VCharron TVillanueva RHarvey KMurello AKutschka ITy KMamczur-Madry MWeisel RHubler SDemers PFleischmann EEggins KSirois CNagpal ADTzemos NGrant KCapoulade RAlexander JBuxton DMorlock JKinzel ENoor ZFiedler ASchonbrodt ADe SKLeshnower BVitanova KBeaudoin JSatitthummanid SThow JPan SUddin SDagenais FBeranek JRahill LSmith TSmith SShults CKempfert JMayer MLPoulin FSoltani RMalas TBlair RCzinn AGeirsson AFang JWilliams JWilliams DHabas RBallazhi FO'Gara PTaddei-Peters WCBoswell HDawood MBolling SFFenton KDe La Cruz HDuncan PKern JRichenbacher WSchonefeld KMoskowitz AJWoo AChristie SGoldfarb SDZeng XFurie KLGonzalez DSellke FGiagiacomo DKoerfgen RSeufert KHakim-Meibodi KDaneshmand MChase MWBader-Wolfle AErola JSugeng LBenjamin-Addy RMarks MESkrypkina DKiaii BHeizmann UCTSN InvestigatorsIkonomidis JSKelsey SFZeh WGeorge TStroh AHarrington KKelly MKSmith RLReeves LMullen JCHalkos MEGreen CVoisine PRiggsbee CMcCullough JOstiguy ACanty JMAslam AMcKenzie FNPhung ATong ZYGray DMartens HLaflamme MDebicki DBForest SGillinov MBaraki HSmith PKMeyer SAcker MABowman MAOverbey JRLange RBaio KFox SAGupta LEscobar JBolling SLaforge FStrippy BBernier MLlerena RJones MLi SFlores TAilawadi GMoon MOsaki SMohr FSham JPettersson GLandry PDickert NO'Sullivan KDolton PRoselli ESledz NMRaymond SHolubkov RRyan WMoquete EBeauchesne LDanner BFaerber GSoukoulis VGrenier SLadowski JCharbonneau EFenlon AHowington BLechner GCartier RReichenspurner HBakaeen FWindhagen HHartmann ADesjardins GNanney TJacques FSvensson LMisfeld MMoore CLarson CDavies AGelijns ACBurks SRupeja NErwin CAkbari FZhang LMick SFumakia NBarrow ECRobichaud SLucas EChan VBakshi KTipton GBagiella EMcCarthy MStokes HWilliams DOBeck KMurphy DBrinkman WYerokun BJessup MStender DJacobs ANorton RStokes CBothe WFielding MJacobs SMack MJDiMaio JMMcPeters LMcCurry KLee AMirsattari SHaney JThain ABouchard DPagani FDSmith JWKapoor SFelbel SJeffries NOGagne NDesvigne-Nickens PThourani VHEaston JDSmith KMSeeburger JBissonauth AKrauspe SCosner JMMaltais SHiesinger WWarshofsky MKSchroder JParides MKPetrov PBadiwala MSimon RZingler BSimon SBorger MADavierwala PBrooks CNawras DWang VStarnes VRatner ALowe SSchlieder RSigler HDiScipio AMardell SVizcaino Risquet LGarg PGaca JFilion IBull DABorger MRoth VGammie JSCunningham MJRodriguez MDellefratte KGuyton RVinkler KSheth HRolbiecki DHung JGeller NLGummert JZagurski APerrault LRixey LRodriguez VKing RSchurzmann RHutcheson KBaker CJTimmons MSong HBergeron ABeyersdorf FMcBride MLam SPausch JAjala Fuentes RGarceau PStojanoska EfalseConcomitant Tricuspid Repair in Patients with Degenerative Mitral Regurgitation.<h4>Background</h4>Tricuspid regurgitation is common in patients with severe degenerative mitral regurgitation. However, the evidence base is insufficient to inform a decision about whether to perform tricuspid-valve repair during mitral-valve surgery in patients who have moderate tricuspid regurgitation or less-than-moderate regurgitation with annular dilatation.<h4>Methods</h4>We randomly assigned 401 patients who were undergoing mitral-valve surgery for degenerative mitral regurgitation to receive a procedure with or without tricuspid annuloplasty (TA). The primary 2-year end point was a composite of reoperation for tricuspid regurgitation, progression of tricuspid regurgitation by two grades from baseline or the presence of severe tricuspid regurgitation, or death.<h4>Results</h4>Patie2022-01-01T00:00:00Z2022 Jan2026-05-09T22:18:41.011Z2025-04-26T13:06:00.039ZS-EPMC87967943476770510.1056/NEJMoa211596110.1056/nejmoa2115961