{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li J"],"funding":["NIA NIH HHS","NHLBI NIH HHS","National Heart, Lung, and Blood Institute","National Natural Science Foundation of China","NINDS NIH HHS","National Institute on Aging"],"pagination":["2503-2510"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8796797"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["190(12)"],"pubmed_abstract":["Growing evidence relates body mass index (BMI) to poorer health outcomes; however, results across studies associating BMI and dementia are conflicting. A total of 3,632 Framingham Offspring participants aged 20 to 60 years at their second health examination (1979-1983) were included in this study, with 190 cases of incident dementia identified by 2017. Cox proportional hazards regression models were fitted to investigate the association of BMI at each of their 8 exams as a baseline for dementia risk and the associations between obesity and dementia across age groups. Spline models were fitted to investigate nonlinear associations between BMI and dementia. Each 1-unit increase in BMI at ages 40-49 years was associated with higher risk of dementia, but with lower risk after age 70 years. Obesity at ages 40-49 years was associated with higher risk of dementia. Overall, the relationship between BMI and dementia risk was heterogeneous across the adult age range. Monitoring BMI at different ages might mediate risk for dementia across an individual's lifetime."],"journal":["American journal of epidemiology"],"pubmed_title":["Mid- to Late-Life Body Mass Index and Dementia Risk: 38 Years of Follow-up of the Framingham Study."],"pmcid":["PMC8796797"],"funding_grant_id":["U19 AG068753","N01-HC-25195","R01 NS017950","R56 AG062109","AG062109","AG068753","AG049810","R01 AG016495","AG008122","R01 AG033040","AG033040","71661167004","AG016495","RF1 AG062109","N01HC25195","R01 AG049810","R01 AG008122"],"pubmed_authors":["Auerbach S","Devine S","Li J","Joshi P","Au R","Liu C","Ang TFA"],"additional_accession":[]},"is_claimable":false,"name":"Mid- to Late-Life Body Mass Index and Dementia Risk: 38 Years of Follow-up of the Framingham Study.","description":"Growing evidence relates body mass index (BMI) to poorer health outcomes; however, results across studies associating BMI and dementia are conflicting. A total of 3,632 Framingham Offspring participants aged 20 to 60 years at their second health examination (1979-1983) were included in this study, with 190 cases of incident dementia identified by 2017. Cox proportional hazards regression models were fitted to investigate the association of BMI at each of their 8 exams as a baseline for dementia risk and the associations between obesity and dementia across age groups. Spline models were fitted to investigate nonlinear associations between BMI and dementia. Each 1-unit increase in BMI at ages 40-49 years was associated with higher risk of dementia, but with lower risk after age 70 years. Obesity at ages 40-49 years was associated with higher risk of dementia. Overall, the relationship between BMI and dementia risk was heterogeneous across the adult age range. Monitoring BMI at different ages might mediate risk for dementia across an individual's lifetime.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2025-04-22T07:48:01.157Z","creation":"2025-04-05T22:21:26.086Z"},"accession":"S-EPMC8796797","cross_references":{"pubmed":["33831181"],"doi":["10.1093/aje/kwab096"]}}