{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(3)"],"submitter":["Yang Y"],"pubmed_abstract":["<h4>Background</h4>We demonstrated that drinking hydrogen-rich water (HRW) inhibits endometrial tumor growth in our previous work. This research is to identify differentially expressed proteins (DEPs) between HRW and purified water groups in a xenograft mouse model of endometrial cancer (EC).<h4>Methods</h4>Samples were analyzed using tandem mass tags (TMTs) coupled with liquid chromatography-tandem mass spectrometry (LC-MS/MS). DEPs were identified using bioinformatics to determine potential molecular functions and immunohistochemical (IHC) staining.<h4>Results</h4>In total, 11 DEPs were identified in the HRW group relative to the control. The up-regulated proteins included Gatad1, Ttyh3, Nek4, Dyrk2, and Gimap1, while the down-regulated proteins included SP1, Msl1, Plekha7, Dtwd2, MSRA, "],"journal":["Translational cancer research"],"pagination":["1295-1312"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8797453"],"repository":["biostudies-literature"],"pubmed_title":["KRAS, YWHAE, SP1 and MSRA as biomarkers in endometrial cancer."],"pmcid":["PMC8797453"],"pubmed_authors":["Sang ZY","Yang Y","Zhu YP","Ma J","Wu SF"],"additional_accession":[]},"is_claimable":false,"name":"KRAS, YWHAE, SP1 and MSRA as biomarkers in endometrial cancer.","description":"<h4>Background</h4>We demonstrated that drinking hydrogen-rich water (HRW) inhibits endometrial tumor growth in our previous work. This research is to identify differentially expressed proteins (DEPs) between HRW and purified water groups in a xenograft mouse model of endometrial cancer (EC).<h4>Methods</h4>Samples were analyzed using tandem mass tags (TMTs) coupled with liquid chromatography-tandem mass spectrometry (LC-MS/MS). DEPs were identified using bioinformatics to determine potential molecular functions and immunohistochemical (IHC) staining.<h4>Results</h4>In total, 11 DEPs were identified in the HRW group relative to the control. The up-regulated proteins included Gatad1, Ttyh3, Nek4, Dyrk2, and Gimap1, while the down-regulated proteins included SP1, Msl1, Plekha7, Dtwd2, MSRA, ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2025-04-19T09:44:05.681Z","creation":"2022-02-11T15:36:11.104Z"},"accession":"S-EPMC8797453","cross_references":{"pubmed":["35116456"],"doi":["10.21037/tcr-20-2969"]}}