{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(2)"],"submitter":["Gao F"],"pubmed_abstract":["<h4>Background</h4>A series of evidence suggests that genetic variation in toll-like receptor (TLR) 9 might influence the outcome of Helicobacter pylori (<i>H. pylori</i>) infection and play an important role in gastric carcinogenesis.<h4>Methods</h4>We conducted a case-control study to evaluate TLR9 polymorphisms on the risk of <i>H. pylori</i> infection and non-cardia gastric cancer (GC) in a Chinese population. We genotyped a tagging single-nucleotide polymorphism (SNP), rs164640, and a potentially functional SNP, rs187084, by TaqMan technique among 288 patients with non-cardia GC and 281 controls. Unconditional logistic regression (LR) was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for SNPs in association with <i>H. pylori</i> infection and non-cardia GC risk"],"journal":["Translational cancer research"],"pagination":["683-689"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8798501"],"repository":["biostudies-literature"],"pubmed_title":["Polymorphisms of <i>TLR9</i> gene are associated with a decreased risk of <i>H. pylori</i> infection in a Chinese population."],"pmcid":["PMC8798501"],"pubmed_authors":["Dong W","Qin J","Tian X","Jia Y","Dang T","Wei X","Gao F"],"additional_accession":[]},"is_claimable":false,"name":"Polymorphisms of <i>TLR9</i> gene are associated with a decreased risk of <i>H. pylori</i> infection in a Chinese population.","description":"<h4>Background</h4>A series of evidence suggests that genetic variation in toll-like receptor (TLR) 9 might influence the outcome of Helicobacter pylori (<i>H. pylori</i>) infection and play an important role in gastric carcinogenesis.<h4>Methods</h4>We conducted a case-control study to evaluate TLR9 polymorphisms on the risk of <i>H. pylori</i> infection and non-cardia gastric cancer (GC) in a Chinese population. We genotyped a tagging single-nucleotide polymorphism (SNP), rs164640, and a potentially functional SNP, rs187084, by TaqMan technique among 288 patients with non-cardia GC and 281 controls. Unconditional logistic regression (LR) was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for SNPs in association with <i>H. pylori</i> infection and non-cardia GC risk","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Feb","modification":"2025-04-05T07:13:18.325Z","creation":"2022-02-11T15:36:05.349Z"},"accession":"S-EPMC8798501","cross_references":{"pubmed":["35117413"],"doi":["10.21037/tcr.2019.11.45"]}}