biostudies-literatureUnknown9(2)Gao F<h4>Background</h4>A series of evidence suggests that genetic variation in toll-like receptor (TLR) 9 might influence the outcome of Helicobacter pylori (<i>H. pylori</i>) infection and play an important role in gastric carcinogenesis.<h4>Methods</h4>We conducted a case-control study to evaluate TLR9 polymorphisms on the risk of <i>H. pylori</i> infection and non-cardia gastric cancer (GC) in a Chinese population. We genotyped a tagging single-nucleotide polymorphism (SNP), rs164640, and a potentially functional SNP, rs187084, by TaqMan technique among 288 patients with non-cardia GC and 281 controls. Unconditional logistic regression (LR) was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for SNPs in association with <i>H. pylori</i> infection and non-cardia GC riskTranslational cancer research683-689https://www.ebi.ac.uk/biostudies/studies/S-EPMC8798501biostudies-literaturePolymorphisms of <i>TLR9</i> gene are associated with a decreased risk of <i>H. pylori</i> infection in a Chinese population.PMC8798501Dong WQin JTian XJia YDang TWei XGao FfalsePolymorphisms of <i>TLR9</i> gene are associated with a decreased risk of <i>H. pylori</i> infection in a Chinese population.<h4>Background</h4>A series of evidence suggests that genetic variation in toll-like receptor (TLR) 9 might influence the outcome of Helicobacter pylori (<i>H. pylori</i>) infection and play an important role in gastric carcinogenesis.<h4>Methods</h4>We conducted a case-control study to evaluate TLR9 polymorphisms on the risk of <i>H. pylori</i> infection and non-cardia gastric cancer (GC) in a Chinese population. We genotyped a tagging single-nucleotide polymorphism (SNP), rs164640, and a potentially functional SNP, rs187084, by TaqMan technique among 288 patients with non-cardia GC and 281 controls. Unconditional logistic regression (LR) was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for SNPs in association with <i>H. pylori</i> infection and non-cardia GC risk2020-01-01T00:00:00Z2020 Feb2025-04-05T07:13:18.325Z2022-02-11T15:36:05.349ZS-EPMC87985013511741310.21037/tcr.2019.11.45