biostudies-literatureSchultz ICconselho nacional de desenvolvimento científico e tecnológicocoordenação de aperfeiçoamento de pessoal de nível superior569-584https://www.ebi.ac.uk/biostudies/studies/S-EPMC8799442biostudies-literatureUnknown100(4)For over a year, the coronavirus disease 2019 has been affecting the world population by causing severe tissue injuries and death in infected people. Adenosine triphosphate (ATP) and the nicotinamide adenine dinucleotide (NAD +) are two molecules that are released into the extracellular microenvironment after direct virus infection or cell death caused by hyper inflammation and coagulopathy. Also, these molecules are well known to participate in multiple pathways and have a pivotal role in the purinergic signaling pathway. Thus, using public datasets available on the Gene Expression Omnibus (GEO), we analyzed raw proteomics data acquired using mass spectrometry (the gold standard method) and raw genomics data from COVID-19 patient samples obtained by microarray. The data was analyzed usingJournal of molecular medicine (Berlin, Germany)Purinergic signaling elements are correlated with coagulation players in peripheral blood and leukocyte samples from COVID-19 patients.PMC8799442MS-SCTIE-DECIT-DGITIS-CGCIS/CNPq nº 26/2020 (442586/2020-5)PNPD postdoc fellowshipMS-SCTIE-Decit/CNPq nº 12/2018 (441575/2018-8)COMBATE-COVID 1694577PBertoni APSSchultz ICWink MRfalsePurinergic signaling elements are correlated with coagulation players in peripheral blood and leukocyte samples from COVID-19 patients.For over a year, the coronavirus disease 2019 has been affecting the world population by causing severe tissue injuries and death in infected people. Adenosine triphosphate (ATP) and the nicotinamide adenine dinucleotide (NAD +) are two molecules that are released into the extracellular microenvironment after direct virus infection or cell death caused by hyper inflammation and coagulopathy. Also, these molecules are well known to participate in multiple pathways and have a pivotal role in the purinergic signaling pathway. Thus, using public datasets available on the Gene Expression Omnibus (GEO), we analyzed raw proteomics data acquired using mass spectrometry (the gold standard method) and raw genomics data from COVID-19 patient samples obtained by microarray. The data was analyzed using2022-01-01T00:00:00Z2022 Apr2026-05-08T18:04:00.114Z2022-02-11T15:40:37.541ZS-EPMC87994423509175910.1007/s00109-021-02175-y