{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["28(1)"],"submitter":["Sinha S"],"pubmed_abstract":["Although critical for host defense, innate immune cells are also pathologic drivers of acute respiratory distress syndrome (ARDS). Innate immune dynamics during Coronavirus Disease 2019 (COVID-19) ARDS, compared to ARDS from other respiratory pathogens, is unclear. Moreover, mechanisms underlying the beneficial effects of dexamethasone during severe COVID-19 remain elusive. Using single-cell RNA sequencing and plasma proteomics, we discovered that, compared to bacterial ARDS, COVID-19 was associated with expansion of distinct neutrophil states characterized by interferon (IFN) and prostaglandin signaling. Dexamethasone during severe COVID-19 affected circulating neutrophils, altered IFN<sup>active</sup> neutrophils, downregulated interferon-stimulated genes and activated IL-1R2<sup>+</sup>"],"journal":["Nature medicine"],"pagination":["201-211"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8799469"],"repository":["biostudies-literature"],"pubmed_title":["Dexamethasone modulates immature neutrophils and interferon programming in severe COVID-19."],"pmcid":["PMC8799469"],"pubmed_authors":["Cao L","Yipp BG","Nguyen AP","Rosin NL","Labit E","Jaffer A","Arora R","Dufour A","Bromley A","Sinha S","Gillrie MR","Biernaskie J","Fritzler MJ","Farias R","de Almeida LGN","McDonald B"],"additional_accession":[]},"is_claimable":false,"name":"Dexamethasone modulates immature neutrophils and interferon programming in severe COVID-19.","description":"Although critical for host defense, innate immune cells are also pathologic drivers of acute respiratory distress syndrome (ARDS). Innate immune dynamics during Coronavirus Disease 2019 (COVID-19) ARDS, compared to ARDS from other respiratory pathogens, is unclear. Moreover, mechanisms underlying the beneficial effects of dexamethasone during severe COVID-19 remain elusive. Using single-cell RNA sequencing and plasma proteomics, we discovered that, compared to bacterial ARDS, COVID-19 was associated with expansion of distinct neutrophil states characterized by interferon (IFN) and prostaglandin signaling. Dexamethasone during severe COVID-19 affected circulating neutrophils, altered IFN<sup>active</sup> neutrophils, downregulated interferon-stimulated genes and activated IL-1R2<sup>+</sup>","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jan","modification":"2026-06-18T05:44:48.089Z","creation":"2025-04-04T08:41:35.409Z"},"accession":"S-EPMC8799469","cross_references":{"pubmed":["34782790"],"doi":["10.1038/s41591-021-01576-3"]}}