{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Guerra LA"],"funding":["American Heart Association","UofI | UIC | Office of the Vice Chancellor for Research, University of Illinois at Chicago","U.S. Department of Health &amp; Human Services | NIH | National Institute of General Medical Sciences","NIA NIH HHS","U.S. Department of Health &amp; Human Services | NIH | National Institute on Aging","NHLBI NIH HHS","U.S. Department of Health &amp; Human Services | NIH | National Heart, Lung, and Blood Institute","NIGMS NIH HHS"],"pagination":["62-68"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8799480"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(1)"],"pubmed_abstract":["Single nucleotide polymorphisms (SNPs) have been associated with differential beta-blocker (BB) effects on heart rate, blood pressure, and left ventricular ejection fraction in various patient populations. This study aimed to determine if SNPs previously associated with BB response are also associated with differential survival in heart failure (HF) patients receiving BBs. HF patient data were derived from electronic health records and the Social Security Death Index. Associations and interactions between BB dose, SNP genotype, and the outcome of death were assessed using a Cox proportional-hazard model adjusting for covariates known to be associated with differential survival in HF patients. Two SNPs, ADRB1 Arg389Gly and ADRB2 Glu27Gln, displayed significant interactions (P<sub>int</sub> "],"journal":["The pharmacogenomics journal"],"pubmed_title":["Genetic polymorphisms in ADRB2 and ADRB1 are associated with differential survival in heart failure patients taking β-blockers."],"pmcid":["PMC8799480"],"funding_grant_id":["R01 HL041281","R03 AG033381","0335361Z","AG033381","K23 GM112014","GM112014","R01 HL136603","HL141281"],"pubmed_authors":["Arwood MJ","Lteif C","McDonough CW","Cavallari LH","Duarte JD","Dumeny L","Guerra LA","Desai AA"],"additional_accession":[]},"is_claimable":false,"name":"Genetic polymorphisms in ADRB2 and ADRB1 are associated with differential survival in heart failure patients taking β-blockers.","description":"Single nucleotide polymorphisms (SNPs) have been associated with differential beta-blocker (BB) effects on heart rate, blood pressure, and left ventricular ejection fraction in various patient populations. This study aimed to determine if SNPs previously associated with BB response are also associated with differential survival in heart failure (HF) patients receiving BBs. HF patient data were derived from electronic health records and the Social Security Death Index. Associations and interactions between BB dose, SNP genotype, and the outcome of death were assessed using a Cox proportional-hazard model adjusting for covariates known to be associated with differential survival in HF patients. Two SNPs, ADRB1 Arg389Gly and ADRB2 Glu27Gln, displayed significant interactions (P<sub>int</sub> ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Feb","modification":"2026-05-29T14:57:43.205Z","creation":"2025-04-04T22:12:09.1Z"},"accession":"S-EPMC8799480","cross_references":{"pubmed":["34642472"],"doi":["10.1038/s41397-021-00257-1"]}}