{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kellermayer R"],"funding":["NIDDK NIH HHS","NIAID NIH HHS"],"pagination":["227-235"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8799498"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["74(2)"],"pubmed_abstract":["<h4>Objectives</h4>Fecal microbiota transplantation (FMT) is arguably the most effective treatment for recurrent Clostridioides difficile infection (rCDI). Clinical reports on pediatric FMT have not systematically evaluated microbiome restoration in patients with co-morbidities. Here, we determined whether FMT recipient age and underlying co-morbidity influenced clinical outcomes and microbiome restoration when treated from shared fecal donor sources.<h4>Methods</h4>Eighteen rCDI patients participating in a single-center, open-label prospective cohort study received fecal preparation from a self-designated (single case) or two universal donors. Twelve age-matched healthy children and four pediatric ulcerative colitis (UC) cases from an independent serial FMT trial, but with a shared fecal "],"journal":["Journal of pediatric gastroenterology and nutrition"],"pubmed_title":["Fecal Microbiota Transplantation Commonly Failed in Children With Co-Morbidities."],"pmcid":["PMC8799498"],"funding_grant_id":["R01 AI100914","P01 AI152999","P30 DK056338","T32 DK007664","R21 DK096323","U01 AI124290","K24 AI121296"],"pubmed_authors":["Kellermayer R","Queliza K","Versalovic J","Wu Q","Nagy-Szakal D","Luna RA","Magee AR","Ihekweazu FD","Spinler JK","Bocchini CE","Hollister EB","Oezguen N","Shulman RJ","Savidge TC"],"additional_accession":[]},"is_claimable":false,"name":"Fecal Microbiota Transplantation Commonly Failed in Children With Co-Morbidities.","description":"<h4>Objectives</h4>Fecal microbiota transplantation (FMT) is arguably the most effective treatment for recurrent Clostridioides difficile infection (rCDI). Clinical reports on pediatric FMT have not systematically evaluated microbiome restoration in patients with co-morbidities. Here, we determined whether FMT recipient age and underlying co-morbidity influenced clinical outcomes and microbiome restoration when treated from shared fecal donor sources.<h4>Methods</h4>Eighteen rCDI patients participating in a single-center, open-label prospective cohort study received fecal preparation from a self-designated (single case) or two universal donors. Twelve age-matched healthy children and four pediatric ulcerative colitis (UC) cases from an independent serial FMT trial, but with a shared fecal ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Feb","modification":"2026-04-08T06:52:33.528Z","creation":"2025-02-19T03:25:54.289Z"},"accession":"S-EPMC8799498","cross_references":{"pubmed":["34724447"],"doi":["10.1097/MPG.0000000000003336","10.1097/mpg.0000000000003336"]}}