biostudies-literatureJacob CResearch Board of the Ghent UniversityBelgian National Fund for Scientific Research | Fonds pour la Formation à la Recherche dans l'Industrie et dans l'AgricultureGhent University (Stevin Supercomputer Infrastructure) VSCFonds De La Recherche Scientifique - FNRSFonds Wetenschappelijk OnderzoekInnoviris560https://www.ebi.ac.uk/biostudies/studies/S-EPMC8799647biostudies-literatureUnknown13(1)A general anti-Baldwin radical 4-exo-dig cyclization from nitrogen-substituted alkynes is reported. Upon reaction with a heteroleptic copper complex in the presence of an amine and under visible light irradiation, a range of ynamides were shown to smoothly cyclize to the corresponding azetidines, useful building blocks in natural product synthesis and medicinal chemistry, with full control of the regioselectivity of the cyclization resulting from a unique and underrated radical 4-exo-dig pathway.Nature communicationsA general synthesis of azetidines by copper-catalysed photoinduced anti-Baldwin radical cyclization of ynamides.PMC87996472019-BRIDGE-5 PhotoCopBIOFACT, Grant No. O019618FBaguia HDubart ALandrain YMichelet BThilmany PEvano GDeldaele CRomero ETheunissen COger SBeaudelot JJacob CVan Speybroeck VPerusko SNeale SMoucheron CfalseA general synthesis of azetidines by copper-catalysed photoinduced anti-Baldwin radical cyclization of ynamides.A general anti-Baldwin radical 4-exo-dig cyclization from nitrogen-substituted alkynes is reported. Upon reaction with a heteroleptic copper complex in the presence of an amine and under visible light irradiation, a range of ynamides were shown to smoothly cyclize to the corresponding azetidines, useful building blocks in natural product synthesis and medicinal chemistry, with full control of the regioselectivity of the cyclization resulting from a unique and underrated radical 4-exo-dig pathway.2022-01-01T00:00:00Z2022 Jan2025-04-18T16:34:38.661Z2025-04-07T03:50:19.114ZS-EPMC87996473509155110.1038/s41467-022-28098-x