{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(1)"],"submitter":["Sun H"],"pubmed_abstract":["Changes in structure of oral solid dosage forms (OSDF) elementally determine the drug release and its therapeutic effects. In this research, synchrotron radiation X-ray micro-computed tomography was utilized to visualize the 3D structure of enteric coated pellets recovered from the gastrointestinal tract of rats. The structures of pellets in solid state and <i>in vitro</i> compendium media were measured. Pellets <i>in vivo</i> underwent morphological and structural changes which differed significantly from those <i>in vitro</i> compendium media. Thus, optimizations of the dissolution media were performed to mimic the appropriate <i>in vivo</i> conditions by introducing pepsin and glass microspheres in media. The sphericity, pellet volume, pore volume and porosity of the <i>in vivo</i> esomeprazole magnesium pellets in stomach for 2 h were recorded 0.47, 1.55 × 10<sup>8</sup> μm<sup>3</sup>, 0.44 × 10<sup>8</sup> μm<sup>3</sup> and 27.6%, respectively. After adding pepsin and glass microspheres, the above parameters <i>in vitro</i> reached to 0.44, 1.64 × 10<sup>8</sup> μm<sup>3</sup>, 0.38 × 10<sup>8</sup> μm<sup>3</sup> and 23.0%, respectively. Omeprazole magnesium pellets behaved similarly. The structural features of pellets between <i>in vitro</i> media and <i>in vivo</i> condition were bridged successfully in terms of 3D structures to ensure better design, characterization and quality control of advanced OSDF."],"journal":["Acta pharmaceutica Sinica. B"],"pagination":["326-338"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8799995"],"repository":["biostudies-literature"],"pubmed_title":["Bridging the structure gap between pellets in artificial dissolution media and in gastro-intestinal tract in rats."],"pmcid":["PMC8799995"],"pubmed_authors":["Yin X","Wu L","Xu M","Ning B","Zhang J","Sun X","Xiao T","York P","He S","Cao Z","Lu S","Sun H","Xu X"],"additional_accession":[]},"is_claimable":false,"name":"Bridging the structure gap between pellets in artificial dissolution media and in gastro-intestinal tract in rats.","description":"Changes in structure of oral solid dosage forms (OSDF) elementally determine the drug release and its therapeutic effects. In this research, synchrotron radiation X-ray micro-computed tomography was utilized to visualize the 3D structure of enteric coated pellets recovered from the gastrointestinal tract of rats. The structures of pellets in solid state and <i>in vitro</i> compendium media were measured. Pellets <i>in vivo</i> underwent morphological and structural changes which differed significantly from those <i>in vitro</i> compendium media. Thus, optimizations of the dissolution media were performed to mimic the appropriate <i>in vivo</i> conditions by introducing pepsin and glass microspheres in media. The sphericity, pellet volume, pore volume and porosity of the <i>in vivo</i> esomeprazole magnesium pellets in stomach for 2 h were recorded 0.47, 1.55 × 10<sup>8</sup> μm<sup>3</sup>, 0.44 × 10<sup>8</sup> μm<sup>3</sup> and 27.6%, respectively. After adding pepsin and glass microspheres, the above parameters <i>in vitro</i> reached to 0.44, 1.64 × 10<sup>8</sup> μm<sup>3</sup>, 0.38 × 10<sup>8</sup> μm<sup>3</sup> and 23.0%, respectively. Omeprazole magnesium pellets behaved similarly. The structural features of pellets between <i>in vitro</i> media and <i>in vivo</i> condition were bridged successfully in terms of 3D structures to ensure better design, characterization and quality control of advanced OSDF.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jan","modification":"2026-03-18T13:43:13.679Z","creation":"2025-05-29T16:07:02.113Z"},"accession":"S-EPMC8799995","cross_references":{"pubmed":["35127389"],"doi":["10.1016/j.apsb.2021.05.010"]}}