{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Molinari PCC"],"funding":["NICHD NIH HHS"],"pagination":["187-198"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8801031"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2(3)"],"pubmed_abstract":["Leptospirosis causes abortion, premature birth, and stillbirth in cattle, but the mechanisms remain unclear. Infected cattle shed <i>Leptospira</i> intermittently and present a range of clinical symptoms, making diagnosis difficult. The primary route of <i>Leptospira</i> transmission in any animal is the colonization of the renal tubule and excretion by urine; however, <i>Leptospira</i> can also colonize the female reproductive tract of cows and can be transmitted by semen. Vaccination against <i>Leptospira</i> in the US is routine in cattle, but immunity is not guaranteed. The cell wall of <i>Leptospira</i> contains toll-like receptor agonists including peptidoglycan and lipopolysaccharide. The capacity of <i>Leptospira</i> to initiate an innate inflammatory response from uterine endometr"],"journal":["Reproduction & fertility"],"pubmed_title":["Bovine endometrial cells do not mount an inflammatory response to <i>Leptospira</i>."],"pmcid":["PMC8801031"],"funding_grant_id":["R01 HD084316"],"pubmed_authors":["Nally JE","Molinari PCC","Bromfield JJ"],"additional_accession":[]},"is_claimable":false,"name":"Bovine endometrial cells do not mount an inflammatory response to <i>Leptospira</i>.","description":"Leptospirosis causes abortion, premature birth, and stillbirth in cattle, but the mechanisms remain unclear. Infected cattle shed <i>Leptospira</i> intermittently and present a range of clinical symptoms, making diagnosis difficult. The primary route of <i>Leptospira</i> transmission in any animal is the colonization of the renal tubule and excretion by urine; however, <i>Leptospira</i> can also colonize the female reproductive tract of cows and can be transmitted by semen. Vaccination against <i>Leptospira</i> in the US is routine in cattle, but immunity is not guaranteed. The cell wall of <i>Leptospira</i> contains toll-like receptor agonists including peptidoglycan and lipopolysaccharide. The capacity of <i>Leptospira</i> to initiate an innate inflammatory response from uterine endometr","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jul","modification":"2026-05-10T00:16:56.009Z","creation":"2022-02-11T15:37:13.002Z"},"accession":"S-EPMC8801031","cross_references":{"pubmed":["35118389"],"doi":["10.1530/RAF-21-0012"]}}