biostudies-literatureMolinari PCCNICHD NIH HHS187-198https://www.ebi.ac.uk/biostudies/studies/S-EPMC8801031biostudies-literatureUnknown2(3)Leptospirosis causes abortion, premature birth, and stillbirth in cattle, but the mechanisms remain unclear. Infected cattle shed Leptospira intermittently and present a range of clinical symptoms, making diagnosis difficult. The primary route of Leptospira transmission in any animal is the colonization of the renal tubule and excretion by urine; however, Leptospira can also colonize the female reproductive tract of cows and can be transmitted by semen. Vaccination against Leptospira in the US is routine in cattle, but immunity is not guaranteed. The cell wall of Leptospira contains toll-like receptor agonists including peptidoglycan and lipopolysaccharide. The capacity of Leptospira to initiate an innate inflammatory response from uterine endometrReproduction & fertilityBovine endometrial cells do not mount an inflammatory response to Leptospira.PMC8801031R01 HD084316Nally JEMolinari PCCBromfield JJfalseBovine endometrial cells do not mount an inflammatory response to Leptospira.Leptospirosis causes abortion, premature birth, and stillbirth in cattle, but the mechanisms remain unclear. Infected cattle shed Leptospira intermittently and present a range of clinical symptoms, making diagnosis difficult. The primary route of Leptospira transmission in any animal is the colonization of the renal tubule and excretion by urine; however, Leptospira can also colonize the female reproductive tract of cows and can be transmitted by semen. Vaccination against Leptospira in the US is routine in cattle, but immunity is not guaranteed. The cell wall of Leptospira contains toll-like receptor agonists including peptidoglycan and lipopolysaccharide. The capacity of Leptospira to initiate an innate inflammatory response from uterine endometr2021-01-01T00:00:00Z2021 Jul2026-05-10T00:16:56.009Z2022-02-11T15:37:13.002ZS-EPMC88010313511838910.1530/RAF-21-0012