{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11"],"submitter":["Si H"],"pubmed_abstract":["Mutated JAK3 has been considered a promising target for cancer therapy. Activating mutations of JAK3 are observed in 3.9%-10% of acute myeloid leukemia (AML) patients, but it is unclear whether AML cells are sensitive to JAK3 inhibitors, and no disease-related human AML cell model has been reported. We have identified U937 as the first human AML cell line expressing the JAK3<sup>M511I</sup> activated mutation and confirmed that JAK3 inhibitors sensitively suppress the proliferation of U937 AML cells."],"journal":["Frontiers in oncology"],"pagination":["807200"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8802890"],"repository":["biostudies-literature"],"pubmed_title":["Identification of U937<sup>JAK3-M511I</sup> Acute Myeloid Leukemia Cells as a Sensitive Model to JAK3 Inhibitor."],"pmcid":["PMC8802890"],"pubmed_authors":["Li J","Li S","Huang J","Zhang Z","Si H","Song X","Tu Z","Wang J","He R","Ding K","Yu X","Tang X"],"additional_accession":[]},"is_claimable":false,"name":"Identification of U937<sup>JAK3-M511I</sup> Acute Myeloid Leukemia Cells as a Sensitive Model to JAK3 Inhibitor.","description":"Mutated JAK3 has been considered a promising target for cancer therapy. Activating mutations of JAK3 are observed in 3.9%-10% of acute myeloid leukemia (AML) patients, but it is unclear whether AML cells are sensitive to JAK3 inhibitors, and no disease-related human AML cell model has been reported. We have identified U937 as the first human AML cell line expressing the JAK3<sup>M511I</sup> activated mutation and confirmed that JAK3 inhibitors sensitively suppress the proliferation of U937 AML cells.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2025-06-01T12:15:12.504Z","creation":"2025-06-01T12:15:12.504Z"},"accession":"S-EPMC8802890","cross_references":{"pubmed":["35111683"],"doi":["10.3389/fonc.2021.807200"]}}