{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Miranda JG"],"funding":["NIDDK NIH HHS","JDRF","NIH"],"pagination":["101430"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8804269"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["57"],"pubmed_abstract":["

Objective

Diabetes occurs because of insufficient insulin secretion due to β-cell dysfunction within the islet of Langerhans. Elevated glucose levels trigger β-cell membrane depolarization, action potential generation, and slow sustained free-Ca2+ ([Ca2+]) oscillations, which trigger insulin release. Nuclear factor of activated T-cell (NFAT) is a transcription factor, which is regulated by the increases in [Ca2+] and calceineurin (CaN) activation. NFAT regulation links cell activity with gene transcription in many systems and regulates proliferation and insulin granule biogenesis within the β-cell. However, the link between the regulation of β-cell electrical activity and oscillatory [Ca2+] dynamics with NFAT activation and downstream tra"],"journal":["Molecular metabolism"],"pubmed_title":["Dynamic changes in β-cell [Ca2+] regulate NFAT activation, gene transcription, and islet gap junction communication."],"pmcid":["PMC8804269"],"funding_grant_id":["F31 DK121488","R01 DK106412","P30 DK116073","R01 DK102950","R56 DK106412"],"pubmed_authors":["Miranda JG","Wells KL","Landgrave SP","Ramirez DG","Schleicher WE","Benninger RKP"],"additional_accession":[]},"is_claimable":false,"name":"Dynamic changes in β-cell [Ca2+] regulate NFAT activation, gene transcription, and islet gap junction communication.","description":"

Objective

Diabetes occurs because of insufficient insulin secretion due to β-cell dysfunction within the islet of Langerhans. Elevated glucose levels trigger β-cell membrane depolarization, action potential generation, and slow sustained free-Ca2+ ([Ca2+]) oscillations, which trigger insulin release. Nuclear factor of activated T-cell (NFAT) is a transcription factor, which is regulated by the increases in [Ca2+] and calceineurin (CaN) activation. NFAT regulation links cell activity with gene transcription in many systems and regulates proliferation and insulin granule biogenesis within the β-cell. However, the link between the regulation of β-cell electrical activity and oscillatory [Ca2+] dynamics with NFAT activation and downstream tra","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-04T19:53:58.218Z","creation":"2025-04-04T19:53:58.218Z"},"accession":"S-EPMC8804269","cross_references":{"pubmed":["34979329"],"doi":["10.1016/j.molmet.2021.101430"]}}