{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Iyengar A"],"funding":["HHS | NIH | National Institute of General Medical Sciences","NIA NIH HHS","HHS | NIH | National Institute of Neurological Disorders and Stroke","Iowa Neuroscience Institute","NINDS NIH HHS","HHS | NIH | National Institute on Aging","NIGMS NIH HHS"],"pagination":["ENEURO.0443-21.2021"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8805199"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(1)"],"pubmed_abstract":["In <i>Drosophila</i>, molecular pathways affecting longevity have been extensively studied. However, corresponding neurophysiological changes underlying aging-related functional and behavioral deteriorations remain to be fully explored. We examined different motor circuits in <i>Drosophila</i> across the life span and uncovered distinctive age-resilient and age-vulnerable trajectories in their established functional properties. In the giant fiber (GF) and downstream circuit elements responsible for the jump-and-flight escape reflex, we observed relatively mild deterioration toward the end of the life span. In contrast, more substantial age-dependent modifications were seen in the plasticity of GF afferent processing, specifically in use dependence and habituation properties. In addition, t"],"journal":["eNeuro"],"pubmed_title":["Distinct Aging-Vulnerable and -Resilient Trajectories of Specific Motor Circuit Functions in Oxidation- and Temperature-Stressed <i>Drosophila</i>."],"pmcid":["PMC8805199"],"funding_grant_id":["AG051513","R01 AG051513","GM088804","NS082001","AG047612","F31 NS082001","R01 GM088804"],"pubmed_authors":["Ruan H","Iyengar A","Wu CF"],"additional_accession":[]},"is_claimable":false,"name":"Distinct Aging-Vulnerable and -Resilient Trajectories of Specific Motor Circuit Functions in Oxidation- and Temperature-Stressed <i>Drosophila</i>.","description":"In <i>Drosophila</i>, molecular pathways affecting longevity have been extensively studied. However, corresponding neurophysiological changes underlying aging-related functional and behavioral deteriorations remain to be fully explored. We examined different motor circuits in <i>Drosophila</i> across the life span and uncovered distinctive age-resilient and age-vulnerable trajectories in their established functional properties. In the giant fiber (GF) and downstream circuit elements responsible for the jump-and-flight escape reflex, we observed relatively mild deterioration toward the end of the life span. In contrast, more substantial age-dependent modifications were seen in the plasticity of GF afferent processing, specifically in use dependence and habituation properties. In addition, t","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jan-Feb","modification":"2026-07-11T03:09:10.686Z","creation":"2026-07-11T03:06:14.987Z"},"accession":"S-EPMC8805199","cross_references":{"pubmed":["34876473"],"doi":["10.1523/ENEURO.0443-21.2021"]}}