biostudies-literatureIyengar AHHS | NIH | National Institute of General Medical SciencesNIA NIH HHSHHS | NIH | National Institute of Neurological Disorders and StrokeIowa Neuroscience InstituteNINDS NIH HHSHHS | NIH | National Institute on AgingNIGMS NIH HHSENEURO.0443-21.2021https://www.ebi.ac.uk/biostudies/studies/S-EPMC8805199biostudies-literatureUnknown9(1)In <i>Drosophila</i>, molecular pathways affecting longevity have been extensively studied. However, corresponding neurophysiological changes underlying aging-related functional and behavioral deteriorations remain to be fully explored. We examined different motor circuits in <i>Drosophila</i> across the life span and uncovered distinctive age-resilient and age-vulnerable trajectories in their established functional properties. In the giant fiber (GF) and downstream circuit elements responsible for the jump-and-flight escape reflex, we observed relatively mild deterioration toward the end of the life span. In contrast, more substantial age-dependent modifications were seen in the plasticity of GF afferent processing, specifically in use dependence and habituation properties. In addition, teNeuroDistinct Aging-Vulnerable and -Resilient Trajectories of Specific Motor Circuit Functions in Oxidation- and Temperature-Stressed <i>Drosophila</i>.PMC8805199AG051513R01 AG051513GM088804NS082001AG047612F31 NS082001R01 GM088804Ruan HIyengar AWu CFfalseDistinct Aging-Vulnerable and -Resilient Trajectories of Specific Motor Circuit Functions in Oxidation- and Temperature-Stressed <i>Drosophila</i>.In <i>Drosophila</i>, molecular pathways affecting longevity have been extensively studied. However, corresponding neurophysiological changes underlying aging-related functional and behavioral deteriorations remain to be fully explored. We examined different motor circuits in <i>Drosophila</i> across the life span and uncovered distinctive age-resilient and age-vulnerable trajectories in their established functional properties. In the giant fiber (GF) and downstream circuit elements responsible for the jump-and-flight escape reflex, we observed relatively mild deterioration toward the end of the life span. In contrast, more substantial age-dependent modifications were seen in the plasticity of GF afferent processing, specifically in use dependence and habituation properties. In addition, t2022-01-01T00:00:00Z2022 Jan-Feb2026-07-11T03:09:10.686Z2026-07-11T03:06:14.987ZS-EPMC88051993487647310.1523/ENEURO.0443-21.2021