biostudies-literatureBecker ACNIAID NIH HHSNHLBI NIH HHSNIGMS NIH HHS822-831https://www.ebi.ac.uk/biostudies/studies/S-EPMC8805604biostudies-literatureUnknown22(9)<h4>Objectives</h4>Soluble MER has emerged as a potential biomarker for delayed resolution of inflammation after myocardial injury and a therapeutic target to reduce cardiac-related morbidity and mortality in adults. The significance of soluble MER in pediatric populations, however, is unclear. We sought to investigate if soluble MER concentrations change in response to myocardial ischemia and reperfusion injury in pediatric patients. In parallel, we also sought to investigate for correlations between the change in soluble MER concentration and specific patient, bypass, and postoperative data.<h4>Design</h4>We quantified the change in plasma soluble MER concentration post- compared with precardiopulmonary bypass for each patient in a cohort of pediatric patients. Linear regression, correlaPediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care SocietiesCardiopulmonary Bypass-Induced Inflammation and Myocardial Ischemia and Reperfusion Injury Stimulates Accumulation of Soluble MER.PMC8805604R01 HL122309P01 AI112522R01 HL139812T32 GM008061Lantz CWEpting CLBecker ACThorp EBForbess JMfalseCardiopulmonary Bypass-Induced Inflammation and Myocardial Ischemia and Reperfusion Injury Stimulates Accumulation of Soluble MER.<h4>Objectives</h4>Soluble MER has emerged as a potential biomarker for delayed resolution of inflammation after myocardial injury and a therapeutic target to reduce cardiac-related morbidity and mortality in adults. The significance of soluble MER in pediatric populations, however, is unclear. We sought to investigate if soluble MER concentrations change in response to myocardial ischemia and reperfusion injury in pediatric patients. In parallel, we also sought to investigate for correlations between the change in soluble MER concentration and specific patient, bypass, and postoperative data.<h4>Design</h4>We quantified the change in plasma soluble MER concentration post- compared with precardiopulmonary bypass for each patient in a cohort of pediatric patients. Linear regression, correla2021-01-01T00:00:00Z2021 Sep2025-04-19T23:13:08.6Z2025-04-19T23:13:08.6ZS-EPMC88056043381354810.1097/PCC.000000000000272510.1097/pcc.0000000000002725