biostudies-literatureRasool MKing Abdulaziz University5099-5109https://www.ebi.ac.uk/biostudies/studies/S-EPMC8806922biostudies-literatureUnknown12(1)Colorectal cancer (CRC) is one of the most important causes of morbidity and mortality in the developed world and is gradually more frequent in the developing world including Saudi Arabia. According to the Saudi Cancer Registry report 2015, CRC is the most common cancer in men (14.9%) and the second most prevalent cancer. Oncogenic mutations in the <i>KRAS</i> gene play a central role in tumorigenesis and are mutated in 30-40% of all CRC patients. To explore the prevalence of <i>KRAS</i> gene mutations in the Saudi population, we collected 80 CRC tumor tissues and sequenced the <i>KRAS</i> gene using automated sequencing technologies. The chromatograms presented mutations in 26 patients (32.5%) in four different codons, that is, 12, 13, 17, and 31. Most of the mutations were identified in BioengineeredDiscovery of a novel and a rare Kristen rat sarcoma viral oncogene homolog (KRAS) gene mutation in colorectal cancer patients.PMC8806922(1-117-1434-HiCi)Al-Sayes FKarim SSibiany AAchakzai NMCarracedo ANatesan Pushparaj PHaque AAsif MRasool MfalseDiscovery of a novel and a rare Kristen rat sarcoma viral oncogene homolog (KRAS) gene mutation in colorectal cancer patients.Colorectal cancer (CRC) is one of the most important causes of morbidity and mortality in the developed world and is gradually more frequent in the developing world including Saudi Arabia. According to the Saudi Cancer Registry report 2015, CRC is the most common cancer in men (14.9%) and the second most prevalent cancer. Oncogenic mutations in the <i>KRAS</i> gene play a central role in tumorigenesis and are mutated in 30-40% of all CRC patients. To explore the prevalence of <i>KRAS</i> gene mutations in the Saudi population, we collected 80 CRC tumor tissues and sequenced the <i>KRAS</i> gene using automated sequencing technologies. The chromatograms presented mutations in 26 patients (32.5%) in four different codons, that is, 12, 13, 17, and 31. Most of the mutations were identified in 2021-01-01T00:00:00Z2021 Dec2025-05-18T12:07:35.487Z2025-04-05T20:12:30.687ZS-EPMC88069223436925610.1080/21655979.2021.1960715