{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Deb B"],"funding":["National Institutes of Health","NIH HHS"],"pagination":["e2600-e2609"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8807322"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["107(6)"],"pubmed_abstract":["<h4>Context</h4>SARS-CoV-2 infects the gastrointestinal tract and may be associated with symptoms that resemble diabetic gastroparesis. Why patients with diabetes who contract COVID-19 are more likely to have severe disease is unknown.<h4>Objective</h4>We aimed to compare the duodenal mucosal expression of SARS-CoV-2 and inflammation-related genes in diabetes gastroenteropathy (DGE), functional dyspepsia (FD), and healthy controls.<h4>Methods</h4>Gastrointestinal transit, and duodenal mucosal mRNA expression of selected genes were compared in 21 controls, 39 DGE patients, and 37 FD patients from a tertiary referral center. Pathway analyses were performed.<h4>Results</h4>Patients had normal, delayed (5 FD [13%] and 13 DGE patients [33%]; P = 0.03 vs controls), or rapid (5 FD [12%] and 5 DGE"],"journal":["The Journal of clinical endocrinology and metabolism"],"pubmed_title":["Duodenal Mucosal Expression of COVID-19-Related Genes in Health, Diabetic Gastroenteropathy, and Functional Dyspepsia."],"pmcid":["PMC8807322"],"funding_grant_id":["R01 DK68055"],"pubmed_authors":["Bharucha AE","Chunawala ZS","O'Brien DR","Deb B"],"additional_accession":[]},"is_claimable":false,"name":"Duodenal Mucosal Expression of COVID-19-Related Genes in Health, Diabetic Gastroenteropathy, and Functional Dyspepsia.","description":"<h4>Context</h4>SARS-CoV-2 infects the gastrointestinal tract and may be associated with symptoms that resemble diabetic gastroparesis. Why patients with diabetes who contract COVID-19 are more likely to have severe disease is unknown.<h4>Objective</h4>We aimed to compare the duodenal mucosal expression of SARS-CoV-2 and inflammation-related genes in diabetes gastroenteropathy (DGE), functional dyspepsia (FD), and healthy controls.<h4>Methods</h4>Gastrointestinal transit, and duodenal mucosal mRNA expression of selected genes were compared in 21 controls, 39 DGE patients, and 37 FD patients from a tertiary referral center. Pathway analyses were performed.<h4>Results</h4>Patients had normal, delayed (5 FD [13%] and 13 DGE patients [33%]; P = 0.03 vs controls), or rapid (5 FD [12%] and 5 DGE","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2025-05-18T12:04:42.56Z","creation":"2025-04-05T20:41:12.775Z"},"accession":"S-EPMC8807322","cross_references":{"pubmed":["35090021"],"doi":["10.1210/clinem/dgac038"]}}