biostudies-literatureDeb BNational Institutes of HealthNIH HHSe2600-e2609https://www.ebi.ac.uk/biostudies/studies/S-EPMC8807322biostudies-literatureUnknown107(6)<h4>Context</h4>SARS-CoV-2 infects the gastrointestinal tract and may be associated with symptoms that resemble diabetic gastroparesis. Why patients with diabetes who contract COVID-19 are more likely to have severe disease is unknown.<h4>Objective</h4>We aimed to compare the duodenal mucosal expression of SARS-CoV-2 and inflammation-related genes in diabetes gastroenteropathy (DGE), functional dyspepsia (FD), and healthy controls.<h4>Methods</h4>Gastrointestinal transit, and duodenal mucosal mRNA expression of selected genes were compared in 21 controls, 39 DGE patients, and 37 FD patients from a tertiary referral center. Pathway analyses were performed.<h4>Results</h4>Patients had normal, delayed (5 FD [13%] and 13 DGE patients [33%]; P = 0.03 vs controls), or rapid (5 FD [12%] and 5 DGEThe Journal of clinical endocrinology and metabolismDuodenal Mucosal Expression of COVID-19-Related Genes in Health, Diabetic Gastroenteropathy, and Functional Dyspepsia.PMC8807322R01 DK68055Bharucha AEChunawala ZSO'Brien DRDeb BfalseDuodenal Mucosal Expression of COVID-19-Related Genes in Health, Diabetic Gastroenteropathy, and Functional Dyspepsia.<h4>Context</h4>SARS-CoV-2 infects the gastrointestinal tract and may be associated with symptoms that resemble diabetic gastroparesis. Why patients with diabetes who contract COVID-19 are more likely to have severe disease is unknown.<h4>Objective</h4>We aimed to compare the duodenal mucosal expression of SARS-CoV-2 and inflammation-related genes in diabetes gastroenteropathy (DGE), functional dyspepsia (FD), and healthy controls.<h4>Methods</h4>Gastrointestinal transit, and duodenal mucosal mRNA expression of selected genes were compared in 21 controls, 39 DGE patients, and 37 FD patients from a tertiary referral center. Pathway analyses were performed.<h4>Results</h4>Patients had normal, delayed (5 FD [13%] and 13 DGE patients [33%]; P = 0.03 vs controls), or rapid (5 FD [12%] and 5 DGE2022-01-01T00:00:00Z2022 May2025-05-18T12:04:42.56Z2025-04-05T20:41:12.775ZS-EPMC88073223509002110.1210/clinem/dgac038