{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Haitao Y"],"funding":["Natural Science Foundation of Hebei Province"],"pagination":["811381"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8807516"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12"],"pubmed_abstract":["Infection caused by antibiotic-resistant microorganisms (ARMs) has been declared a global threat to public health. Polymeric nanoparticles (PNPs) formed by antimicrobial peptides (AMPs) and synthetic PNPs against ARM infections are emerging. PNPs are also considered to be a promising natural biological preservative that prevents microbial spoilage through food processing and preservation. We engineered CNMs, a novel nanocomposite antibacterial agent based on chitosan nanoparticles and AMP microcin J25. In this study, we aimed to evaluate the comprehensive antimicrobial activity, potential antimicrobial mechanism, and anti-inflammatory activity of CNMs. We demonstrated that CNMs harbor excellent bactericidal activity against clinical foodborne pathogens and ARMs. CNMs caused fast mortality "],"journal":["Frontiers in immunology"],"pubmed_title":["A Novel Polymeric Nanohybrid Antimicrobial Engineered by Antimicrobial Peptide MccJ25 and Chitosan Nanoparticles Exerts Strong Antibacterial and Anti-Inflammatory Activities."],"pmcid":["PMC8807516"],"funding_grant_id":["C2021204161"],"pubmed_authors":["Yifan C","Haitao Y","Mingchao S","Shuaijuan H"],"additional_accession":[]},"is_claimable":false,"name":"A Novel Polymeric Nanohybrid Antimicrobial Engineered by Antimicrobial Peptide MccJ25 and Chitosan Nanoparticles Exerts Strong Antibacterial and Anti-Inflammatory Activities.","description":"Infection caused by antibiotic-resistant microorganisms (ARMs) has been declared a global threat to public health. Polymeric nanoparticles (PNPs) formed by antimicrobial peptides (AMPs) and synthetic PNPs against ARM infections are emerging. PNPs are also considered to be a promising natural biological preservative that prevents microbial spoilage through food processing and preservation. We engineered CNMs, a novel nanocomposite antibacterial agent based on chitosan nanoparticles and AMP microcin J25. In this study, we aimed to evaluate the comprehensive antimicrobial activity, potential antimicrobial mechanism, and anti-inflammatory activity of CNMs. We demonstrated that CNMs harbor excellent bactericidal activity against clinical foodborne pathogens and ARMs. CNMs caused fast mortality ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2026-03-31T10:56:59.744Z","creation":"2025-04-04T21:33:34.131Z"},"accession":"S-EPMC8807516","cross_references":{"pubmed":["35126369"],"doi":["10.3389/fimmu.2021.811381"]}}