{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15"],"submitter":["Dolatshahi M"],"pubmed_abstract":["<h4>Background</h4>The history of intracranial hemorrhage (ICrH) is considered a contraindication for intravenous thrombolysis (IVT) among patients with acute ischemic stroke (AIS). Objective: This study aimed at comparing the safety of IVT among patients with and without a history of ICrH.<h4>Methods</h4>We performed a systematic review of the literature. Data regarding all AIS patients with prior ICrH who received IVT were retrieved. Meta-analysis was performed to compare the rate of symptomatic hemorrhagic transformation (sHT), death within 90 days, and favorable and unfavorable 90-day functional outcomes based on modified Rankin Scale (mRS) among stroke patients with and without prior ICrH.<h4>Results</h4>Out of 13,032 reviewed records, 7 studies were included in the systematic review "],"journal":["Therapeutic advances in neurological disorders"],"pagination":["17562864221074144"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8808019"],"repository":["biostudies-literature"],"pubmed_title":["Intravenous thrombolysis in ischemic stroke patients with a prior intracranial hemorrhage: a meta-analysis."],"pmcid":["PMC8808019"],"pubmed_authors":["Koza E","Dolatshahi M","Abedi V","Zand R","Shahjouei S","Sabahi M"],"additional_accession":[]},"is_claimable":false,"name":"Intravenous thrombolysis in ischemic stroke patients with a prior intracranial hemorrhage: a meta-analysis.","description":"<h4>Background</h4>The history of intracranial hemorrhage (ICrH) is considered a contraindication for intravenous thrombolysis (IVT) among patients with acute ischemic stroke (AIS). Objective: This study aimed at comparing the safety of IVT among patients with and without a history of ICrH.<h4>Methods</h4>We performed a systematic review of the literature. Data regarding all AIS patients with prior ICrH who received IVT were retrieved. Meta-analysis was performed to compare the rate of symptomatic hemorrhagic transformation (sHT), death within 90 days, and favorable and unfavorable 90-day functional outcomes based on modified Rankin Scale (mRS) among stroke patients with and without prior ICrH.<h4>Results</h4>Out of 13,032 reviewed records, 7 studies were included in the systematic review ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-25T21:59:22.669Z","creation":"2025-04-06T08:58:35.028Z"},"accession":"S-EPMC8808019","cross_references":{"pubmed":["35126671"],"doi":["10.1177/17562864221074144"]}}