biostudies-literatureMestriner ABVericel Corporation1298S-1305Shttps://www.ebi.ac.uk/biostudies/studies/S-EPMC8808922biostudies-literatureUnknown13(1_suppl)<h4>Objective</h4>To determine the relationship between cartilage lesion etiology and clinical outcomes after second-generation autologous chondrocyte implantation (ACI) in the patellofemoral joint (PFJ) with a minimum of 2 years' follow-up.<h4>Methods</h4>A retrospective review of all patients that underwent ACI in the PFJ by a single surgeon was performed. Seventy-two patients with a mean follow-up of 4.2 ± 2.0 years were enrolled in this study and were stratified into 3 groups based on the etiology of PFJ cartilage lesions: patellar dislocation (group 1; <i>n</i> = 23); nontraumatic lesions, including chondromalacia, osteochondritis dissecans, and degenerative defects (group 2; <i>n</i> = 28); and other posttraumatic lesions besides patellar dislocations (group 3; <i>n</i> = 21). PatienCartilageEtiology of Cartilage Lesions Does Not Affect Clinical Outcomes of Patellofemoral Autologous Chondrocyte Implantation.PMC880892220180814Mestriner ABMerkely GAmbra LFMGomoll AHAckermann JGalvao PHSAFfalseEtiology of Cartilage Lesions Does Not Affect Clinical Outcomes of Patellofemoral Autologous Chondrocyte Implantation.<h4>Objective</h4>To determine the relationship between cartilage lesion etiology and clinical outcomes after second-generation autologous chondrocyte implantation (ACI) in the patellofemoral joint (PFJ) with a minimum of 2 years' follow-up.<h4>Methods</h4>A retrospective review of all patients that underwent ACI in the PFJ by a single surgeon was performed. Seventy-two patients with a mean follow-up of 4.2 ± 2.0 years were enrolled in this study and were stratified into 3 groups based on the etiology of PFJ cartilage lesions: patellar dislocation (group 1; <i>n</i> = 23); nontraumatic lesions, including chondromalacia, osteochondritis dissecans, and degenerative defects (group 2; <i>n</i> = 28); and other posttraumatic lesions besides patellar dislocations (group 3; <i>n</i> = 21). Patien2021-01-01T00:00:00Z2021 Dec2025-04-04T07:47:55.721Z2025-04-04T07:47:55.721ZS-EPMC88089223428661910.1177/19476035211030991