biostudies-literatureReukers DFMStichting Q-supporte0263239https://www.ebi.ac.uk/biostudies/studies/S-EPMC8809529biostudies-literatureUnknown17(2)<h4>Background</h4>This study aimed to determine short- and long-term physical and psychosocial impact of Coxiella burnetii infection in three distinct entities: Q-fever fatigue syndrome (QFS), chronic Q-fever, and patients with past acute Q-fever without QFS or chronic Q-fever.<h4>Methods</h4>Integrative data analysis was performed, combining original data from eight studies measuring quality of life (QoL), fatigue, physical and social functioning with identical validated questionnaires, from three months to eight years after onset infection. Linear trends in each outcome were compared between Q-fever groups using multilevel linear regression analyses to account for repeated measures within patients.<h4>Results</h4>Data included 3947 observations of 2313 individual patients (228 QFS, 135 PloS oneImpact of Q-fever on physical and psychosocial functioning until 8 years after Coxiella burnetii infection: An integrative data analysis.PMC8809529AMPHI150114-00Keijmel SPvan Dam ASGMorroy Gvan Loenhout JAFvan der Velden KWever PCReukers DFMvan Jaarsveld CHMHautvast JLAAkkermans RPWielders CCHfalseImpact of Q-fever on physical and psychosocial functioning until 8 years after Coxiella burnetii infection: An integrative data analysis.<h4>Background</h4>This study aimed to determine short- and long-term physical and psychosocial impact of Coxiella burnetii infection in three distinct entities: Q-fever fatigue syndrome (QFS), chronic Q-fever, and patients with past acute Q-fever without QFS or chronic Q-fever.<h4>Methods</h4>Integrative data analysis was performed, combining original data from eight studies measuring quality of life (QoL), fatigue, physical and social functioning with identical validated questionnaires, from three months to eight years after onset infection. Linear trends in each outcome were compared between Q-fever groups using multilevel linear regression analyses to account for repeated measures within patients.<h4>Results</h4>Data included 3947 observations of 2313 individual patients (228 QFS, 135 2022-01-01T00:00:00Z20222025-04-03T22:08:34.365Z2024-10-15T12:53:33.133ZS-EPMC88095293510833010.1371/journal.pone.0263239