{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Das JK"],"funding":["NIAID NIH HHS","NCI NIH HHS"],"pagination":["eabl9783"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8809536"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(5)"],"pubmed_abstract":["eEF-2K has important roles in stress responses and cellular metabolism. We report here a previously unappreciated but critical role of eEF-2K in regulating the fate and cytocidal activity of CD8<sup>+</sup> T cells. CD8<sup>+</sup> T cells from eEF-2K KO mice were more proliferative but had lower survival than their wild-type counterparts after their activation, followed by occurrence of premature senescence and exhaustion. eEF-2K KO CD8<sup>+</sup> T cells were more metabolically active and showed hyperactivation of the Akt-mTOR-S6K pathway. Loss of eEF-2K substantially impaired the activity of CD8<sup>+</sup> T cells. Furthermore, the antitumor efficacy and tumor infiltration of the CAR-CD8<sup>+</sup> T cells lacking eEF-2K were notably reduced as compared to the control CAR-CD8<sup>+</"],"journal":["Science advances"],"pubmed_title":["Elongation factor-2 kinase is a critical determinant of the fate and antitumor immunity of CD8<sup>+</sup> T cells."],"pmcid":["PMC8809536"],"funding_grant_id":["R01 CA221867","R01 AI121180","R21 AI167793","R21 AI128325"],"pubmed_authors":["Ren X","Ren Y","Peng HY","Yang JM","Song J","Wang L","Xiong X","Liu X","Ryazonov AG","de Figueiredo P","Alaniz RC","Kumar A","Das JK"],"additional_accession":[]},"is_claimable":false,"name":"Elongation factor-2 kinase is a critical determinant of the fate and antitumor immunity of CD8<sup>+</sup> T cells.","description":"eEF-2K has important roles in stress responses and cellular metabolism. We report here a previously unappreciated but critical role of eEF-2K in regulating the fate and cytocidal activity of CD8<sup>+</sup> T cells. CD8<sup>+</sup> T cells from eEF-2K KO mice were more proliferative but had lower survival than their wild-type counterparts after their activation, followed by occurrence of premature senescence and exhaustion. eEF-2K KO CD8<sup>+</sup> T cells were more metabolically active and showed hyperactivation of the Akt-mTOR-S6K pathway. Loss of eEF-2K substantially impaired the activity of CD8<sup>+</sup> T cells. Furthermore, the antitumor efficacy and tumor infiltration of the CAR-CD8<sup>+</sup> T cells lacking eEF-2K were notably reduced as compared to the control CAR-CD8<sup>+</","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Feb","modification":"2026-06-04T04:37:44.405Z","creation":"2024-10-16T10:39:26.234Z"},"accession":"S-EPMC8809536","cross_references":{"pubmed":["35108044"],"doi":["10.1126/sciadv.abl9783"]}}