biostudies-literatureBhuiyan TRNIAID NIH HHSFIC NIH HHS198-203https://www.ebi.ac.uk/biostudies/studies/S-EPMC8809641biostudies-literatureUnknown2<h4>Design</h4>A cross-sectional study was conducted amongst household members in 32 districts of Bangladesh to build knowledge about disease epidemiology and seroepidemiology of coronavirus disease 2019 (COVID-19).<h4>Objective</h4>Antibody responses to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) were assessed in people between April and October 2020.<h4>Results</h4>The national seroprevalence rates of immunoglobulin G (IgG) and IgM were estimated to be 30.4% and 39.7%, respectively. In Dhaka, the seroprevalence of IgG was 35.4% in non-slum areas and 63.5% in slum areas. In areas outside of Dhaka, the seroprevalence of IgG was 37.5% in urban areas and 28.7% in rural areas. Between April and October 2020, the highest seroprevalence rate (57% for IgG and 64% for IgM) was observed in August. IgM antibody was more prevalent in younger participants, while older participants had more frequent IgG seropositivity. Follow-up specimens from patients with COVID-19 and their household members suggested that both IgG and IgM seropositivity increased significantly at day 14 and day 28 compared with day 1 after enrolment. <i>Conclusions</i>: SARS-CoV-2 had spread extensively in Bangladesh by October 2020. This highlights the importance of monitoring seroprevalence data, particularly with the emergence of new SARS-CoV-2 variants over time.IJID regionsSeroprevalence of SARS-CoV-2 antibodies in Bangladesh related to novel coronavirus infection.PMC8809641R01 AI130378K43 TW010362Charles RCArifeen SEQadri FBablu ARAlamgir ASMFerdous JRahman SIAHossain KShirin TCalderwood SBAkhtar MFlora MSNazneen ATony SRLaRocque RCBhuiyan TRAkter AKhaton FHarris JBRahman MSumon SABanik KCBanu SRyan ETChakraborty NfalseSeroprevalence of SARS-CoV-2 antibodies in Bangladesh related to novel coronavirus infection.<h4>Design</h4>A cross-sectional study was conducted amongst household members in 32 districts of Bangladesh to build knowledge about disease epidemiology and seroepidemiology of coronavirus disease 2019 (COVID-19).<h4>Objective</h4>Antibody responses to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) were assessed in people between April and October 2020.<h4>Results</h4>The national seroprevalence rates of immunoglobulin G (IgG) and IgM were estimated to be 30.4% and 39.7%, respectively. In Dhaka, the seroprevalence of IgG was 35.4% in non-slum areas and 63.5% in slum areas. In areas outside of Dhaka, the seroprevalence of IgG was 37.5% in urban areas and 28.7% in rural areas. Between April and October 2020, the highest seroprevalence rate (57% for IgG and 64% for IgM) was observed in August. IgM antibody was more prevalent in younger participants, while older participants had more frequent IgG seropositivity. Follow-up specimens from patients with COVID-19 and their household members suggested that both IgG and IgM seropositivity increased significantly at day 14 and day 28 compared with day 1 after enrolment. <i>Conclusions</i>: SARS-CoV-2 had spread extensively in Bangladesh by October 2020. This highlights the importance of monitoring seroprevalence data, particularly with the emergence of new SARS-CoV-2 variants over time.2022-01-01T00:00:00Z2022 Mar2025-04-18T12:19:23.713Z2025-04-06T21:48:50.771ZS-EPMC88096413572142610.1016/j.ijregi.2022.01.013