biostudies-literatureJohn BVNCATS NIH HHSNCI NIH HHSDivision of Cancer Prevention, National Cancer Institute384-393https://www.ebi.ac.uk/biostudies/studies/S-EPMC8810619biostudies-literatureUnknown42(2)<h4>Background</h4>The natural history of patients with anti-mitochondrial antibody (AMA)-negative Primary Biliary Cholangitis (PBC) cirrhosis has not been well defined, with prior studies showing discordant results. Furthermore, most studies of AMA-negative PBC have limited numbers of patients with cirrhosis and liver-related outcomes.<h4>Methods</h4>We investigated the association of AMA-negative PBC and the development of death, liver-related death, decompensation and hepatocellular carcinoma (HCC), in a large cohort of predominantly male patients with PBC cirrhosis assembled from the Veterans Health Administration.<h4>Results</h4>In a cohort of 521 patients with PBC cirrhosis (65 AMA-negative) with a total follow-up of 2504.3 person-years (PY) from cirrhosis diagnosis, patients with AMLiver international : official journal of the International Association for the Study of the LiverRates of decompensation, hepatocellular carcinoma and mortality in AMA-negative primary biliary cholangitis cirrhosis.PMC8810619UL1 TR001863P30 CA016059Dahman BKhakoo NSLevy CJohn BVTaddei THDeng YKaplan DEfalseRates of decompensation, hepatocellular carcinoma and mortality in AMA-negative primary biliary cholangitis cirrhosis.<h4>Background</h4>The natural history of patients with anti-mitochondrial antibody (AMA)-negative Primary Biliary Cholangitis (PBC) cirrhosis has not been well defined, with prior studies showing discordant results. Furthermore, most studies of AMA-negative PBC have limited numbers of patients with cirrhosis and liver-related outcomes.<h4>Methods</h4>We investigated the association of AMA-negative PBC and the development of death, liver-related death, decompensation and hepatocellular carcinoma (HCC), in a large cohort of predominantly male patients with PBC cirrhosis assembled from the Veterans Health Administration.<h4>Results</h4>In a cohort of 521 patients with PBC cirrhosis (65 AMA-negative) with a total follow-up of 2504.3 person-years (PY) from cirrhosis diagnosis, patients with AM2022-01-01T00:00:00Z2022 Feb2025-04-21T15:51:15.992Z2025-04-21T15:51:15.992ZS-EPMC88106193461429410.1111/liv.15079