biostudies-literatureYang XShanghai Hospital Development Center6258268https://www.ebi.ac.uk/biostudies/studies/S-EPMC8811541biostudies-literatureUnknown2022<h4>Background</h4>Recent studies have shown that the expression level of triosephosphate isomerase 1 (<i>TPI1</i>) may be associated with the occurrence and metastasis of tumors, but the expression level of <i>TPI1</i> and its effect on lung adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC) are not yet clear.<h4>Methods</h4>We comprehensively explored and validated the <i>TPI1</i> expression in lung adenocarcinoma and lung squamous cell carcinoma in public datasets. The associations of <i>TPI1</i> expression with clinicopathological characteristics and prognosis were also studied in both histological types. Moreover, we analyzed the potential relations of <i>TPI1</i> with immunomodulators and immune cell infiltrations in the tumor microenvironment based on previous literatures and bioinformatic tools.<h4>Results</h4>We found that <i>TPI1</i> was significantly overexpressed in LUAD and LUSC. Significant associations of <i>TPI1</i> expression were observed regarding age, gender, and pathological stages in LUAD. However, similar trend was only found with respect to age in LUSC. The high expression of <i>TPI1</i> was significantly associated with worse survival in LUAD, but not in LUSC. Furthermore, we explored the potential distribution and changes of <i>TPI1</i> expression in tumor microenvironment. Pathway enrichment analyses were performed to identify possible roles of <i>TPI1</i> in both lung cancers.<h4>Conclusions</h4><i>TPI1</i> was overexpressed in both LUAD and LUSC. Increased <i>TPI1</i> expression was correlated with poor prognosis in LUAD and changed immune cell infiltrating in various degrees in both histological types. Our study provides insights in understanding the potential roles of <i>TPI1</i> in tumor progression and immune microenvironment.Disease markersSystemic Analyses of the Expression of TPI1 and Its Associations with Tumor Microenvironment in Lung Adenocarcinoma and Squamous Cell Carcinoma.PMC8811541SHDC2020CR402818CG1920QA14083008200008481802256FKYQ190721YF1438600Yang XZheng HDai CZhu YYe CfalseSystemic Analyses of the Expression of TPI1 and Its Associations with Tumor Microenvironment in Lung Adenocarcinoma and Squamous Cell Carcinoma.<h4>Background</h4>Recent studies have shown that the expression level of triosephosphate isomerase 1 (<i>TPI1</i>) may be associated with the occurrence and metastasis of tumors, but the expression level of <i>TPI1</i> and its effect on lung adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC) are not yet clear.<h4>Methods</h4>We comprehensively explored and validated the <i>TPI1</i> expression in lung adenocarcinoma and lung squamous cell carcinoma in public datasets. The associations of <i>TPI1</i> expression with clinicopathological characteristics and prognosis were also studied in both histological types. Moreover, we analyzed the potential relations of <i>TPI1</i> with immunomodulators and immune cell infiltrations in the tumor microenvironment based on previous literatures and bioinformatic tools.<h4>Results</h4>We found that <i>TPI1</i> was significantly overexpressed in LUAD and LUSC. Significant associations of <i>TPI1</i> expression were observed regarding age, gender, and pathological stages in LUAD. However, similar trend was only found with respect to age in LUSC. The high expression of <i>TPI1</i> was significantly associated with worse survival in LUAD, but not in LUSC. Furthermore, we explored the potential distribution and changes of <i>TPI1</i> expression in tumor microenvironment. Pathway enrichment analyses were performed to identify possible roles of <i>TPI1</i> in both lung cancers.<h4>Conclusions</h4><i>TPI1</i> was overexpressed in both LUAD and LUSC. Increased <i>TPI1</i> expression was correlated with poor prognosis in LUAD and changed immune cell infiltrating in various degrees in both histological types. Our study provides insights in understanding the potential roles of <i>TPI1</i> in tumor progression and immune microenvironment.2022-01-01T00:00:00Z20222024-11-20T02:28:05.463Z2024-11-20T02:28:05.463ZS-EPMC88115413512678810.1155/2022/6258268