biostudies-literatureWainaina MDeutscher Akademischer Austauschdienste0010144https://www.ebi.ac.uk/biostudies/studies/S-EPMC8812962biostudies-literatureUnknown16(1)<h4>Background</h4>The awareness of non-malarial febrile illnesses (NMFIs) has been on the rise over the last decades. Therefore, we undertook a systematic literature review and meta-analysis of causative agents of non-malarial fevers on the African continent.<h4>Methodology</h4>We searched for literature in African Journals Online, EMBASE, PubMed, Scopus, and Web of Science databases to identify aetiologic agents that had been reported and to determine summary estimates of the proportional morbidity rates (PMr) associated with these pathogens among fever patients.<h4>Findings</h4>A total of 133 studies comprising 391,835 patients from 25 of the 54 African countries were eligible. A wide array of aetiologic agents were described with considerable regional differences among the leading agenPLoS neglected tropical diseasesA systematic review and meta-analysis of the aetiological agents of non-malarial febrile illnesses in Africa.PMC8812962Ref. No.: 91693043Bett BAl Dahouk SHofreuter DRoesler UDohoo IMayer-Scholl AWainaina MLindahl JRoesel KVey da Silva DAfalseA systematic review and meta-analysis of the aetiological agents of non-malarial febrile illnesses in Africa.<h4>Background</h4>The awareness of non-malarial febrile illnesses (NMFIs) has been on the rise over the last decades. Therefore, we undertook a systematic literature review and meta-analysis of causative agents of non-malarial fevers on the African continent.<h4>Methodology</h4>We searched for literature in African Journals Online, EMBASE, PubMed, Scopus, and Web of Science databases to identify aetiologic agents that had been reported and to determine summary estimates of the proportional morbidity rates (PMr) associated with these pathogens among fever patients.<h4>Findings</h4>A total of 133 studies comprising 391,835 patients from 25 of the 54 African countries were eligible. A wide array of aetiologic agents were described with considerable regional differences among the leading agen2022-01-01T00:00:00Z2022 Jan2025-04-05T13:57:50.228Z2025-04-05T13:57:50.228ZS-EPMC88129623507330910.1371/journal.pntd.0010144