{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Landowski CP"],"funding":["NIAID NIH HHS"],"pagination":["2418-24"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC88164"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["39(7)"],"pubmed_abstract":["Laboratory diagnosis of tuberculosis is often difficult. Immunodetection of circulating Mycobacterium tuberculosis proteins shed during active infection would not depend on an intact host immune response and could take advantage of the speed and low costs afforded by antibody-based assays. We previously showed that patients with active tuberculosis had increased levels of circulating antigen 85 (Ag85) proteins independent of their tuberculin skin test status (S. I. Bentley-Hibbert, X. Quan, T. Newman, K. Huygen, and H. P. Godfrey, Infect. Immun. 67:581-588, 1999). To extend these observations to a Mycobacterium bovis BCG-vaccinated population and to another secreted mycobacterial protein, Ag85 and PstS-1 (protein antigen B, p38 antigen) were quantified in sera from 97 Chilean tuberculosis "],"journal":["Journal of clinical microbiology"],"pubmed_title":["Combinatorial use of antibodies to secreted mycobacterial proteins in a host immune system-independent test for tuberculosis."],"pmcid":["PMC88164"],"funding_grant_id":["AI42452","AI36989","R01 AI036989","AI45925"],"pubmed_authors":["Liu X","Gennaro ML","Moy FH","Huang Z","Godfrey HP","Haak-Frendscho M","Landowski CP","Sepulveda R","Huygen K","Bentley-Hibbert SI","Lesley SA"],"additional_accession":[]},"is_claimable":false,"name":"Combinatorial use of antibodies to secreted mycobacterial proteins in a host immune system-independent test for tuberculosis.","description":"Laboratory diagnosis of tuberculosis is often difficult. Immunodetection of circulating Mycobacterium tuberculosis proteins shed during active infection would not depend on an intact host immune response and could take advantage of the speed and low costs afforded by antibody-based assays. We previously showed that patients with active tuberculosis had increased levels of circulating antigen 85 (Ag85) proteins independent of their tuberculin skin test status (S. I. Bentley-Hibbert, X. Quan, T. Newman, K. Huygen, and H. P. Godfrey, Infect. Immun. 67:581-588, 1999). To extend these observations to a Mycobacterium bovis BCG-vaccinated population and to another secreted mycobacterial protein, Ag85 and PstS-1 (protein antigen B, p38 antigen) were quantified in sera from 97 Chilean tuberculosis ","dates":{"release":"2001-01-01T00:00:00Z","publication":"2001 Jul","modification":"2025-04-21T19:07:41.994Z","creation":"2019-06-06T21:13:36Z"},"accession":"S-EPMC88164","cross_references":{"pubmed":["11427548"],"doi":["10.1128/jcm.39.7.2418-2424.2001","10.1128/JCM.39.7.2418-2424.2001"]}}