biostudies-literatureYin YShaanxi Provincial Science and Technology DepartmentXinjiang Guan Run Logistics Co., LtdRuilan JiangNational Natural Science Foundation of China71https://www.ebi.ac.uk/biostudies/studies/S-EPMC8817485biostudies-literatureUnknown20(1)<h4>Background</h4>Cancer screening provides the opportunity to detect cancer early, ideally before symptom onset and metastasis, and offers an increased opportunity for a better prognosis. The ideal biomarkers for cancer screening should discriminate individuals who have not developed invasive cancer yet but are destined to do so from healthy subjects. However, most cancers lack effective screening recommendations. Therefore, further studies on novel screening strategies are urgently required.<h4>Methods</h4>We used a simple suboptimal inoculation melanoma mouse model to obtain 'pre-diagnostic samples' of mice with macroscopic melanomas. High-throughput sequencing and bioinformatic analysis were employed to identify differentially expressed RNAs in platelet signatures of mice injected witJournal of translational medicinePrediction of occult tumor progression via platelet RNAs in a mouse melanoma model: a potential new platform for early detection of cancer.PMC8817485816026982019JQ-59120181224Yin YShen MShi LZhang KYan NJiang HJiang RWang LChen DLv JLiu XLi ZFeng JfalsePrediction of occult tumor progression via platelet RNAs in a mouse melanoma model: a potential new platform for early detection of cancer.<h4>Background</h4>Cancer screening provides the opportunity to detect cancer early, ideally before symptom onset and metastasis, and offers an increased opportunity for a better prognosis. The ideal biomarkers for cancer screening should discriminate individuals who have not developed invasive cancer yet but are destined to do so from healthy subjects. However, most cancers lack effective screening recommendations. Therefore, further studies on novel screening strategies are urgently required.<h4>Methods</h4>We used a simple suboptimal inoculation melanoma mouse model to obtain 'pre-diagnostic samples' of mice with macroscopic melanomas. High-throughput sequencing and bioinformatic analysis were employed to identify differentially expressed RNAs in platelet signatures of mice injected wit2022-01-01T00:00:00Z2022 Feb2025-04-05T22:58:33.288Z2025-02-19T03:47:07.184ZS-EPMC88174853512349910.1186/s12967-022-03268-z