biostudies-literatureUnknown13Colucci MFondazione Bambino GesùThe therapeutic efficacy of B-cell depletion by anti-CD20 treatment in pediatric and, more recently, in adult idiopathic nephrotic syndrome patients suggests a key role of B cells in the pathogenesis of the disease. However, their exact role is still unclear. B cells are able to secrete a large variety of antibodies that can protect against infections. However, B-cell dysregulation is well-established in a variety of autoimmune diseases. In parallel with their ability to produce antibodies, pathogenic B cells display altered effector functions by expressing activating surface molecules, which can strongly modify the immune homeostasis, or by producing specific cytokines, which can directly affect either podocyte structure and functions or modulate T-cell homeostasis. Herein, we report the Frontiers in immunology823204https://www.ebi.ac.uk/biostudies/studies/S-EPMC8819007biostudies-literatureB-Cell Dysregulation in Idiopathic Nephrotic Syndrome: What We Know and What We Need to Discover.PMC8819007Vivarelli MColucci MOniszczuk JAudard VfalseB-Cell Dysregulation in Idiopathic Nephrotic Syndrome: What We Know and What We Need to Discover.The therapeutic efficacy of B-cell depletion by anti-CD20 treatment in pediatric and, more recently, in adult idiopathic nephrotic syndrome patients suggests a key role of B cells in the pathogenesis of the disease. However, their exact role is still unclear. B cells are able to secrete a large variety of antibodies that can protect against infections. However, B-cell dysregulation is well-established in a variety of autoimmune diseases. In parallel with their ability to produce antibodies, pathogenic B cells display altered effector functions by expressing activating surface molecules, which can strongly modify the immune homeostasis, or by producing specific cytokines, which can directly affect either podocyte structure and functions or modulate T-cell homeostasis. Herein, we report the 2022-01-01T00:00:00Z20222025-04-04T09:24:35.36Z2024-11-09T12:00:48.225ZS-EPMC88190073514072310.3389/fimmu.2022.823204