{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang PC"],"funding":["Ministry of Science and Technology","Fudan University","National Natural Science Foundation of China","Shanghai International Science and Technology","Shanghai International Science and Technology Collaboration Program","Major Special Projects of the Ministry of Science and Technology","Fundamental Medical Project of Minhang Hospital of the Fudan University Project Foundation"],"pagination":["423-431"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8819352"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["113(2)"],"pubmed_abstract":["Infiltrating immune cells in the tumor microenvironment (TME) influence tumor progression and patient prognosis, making them attractive therapeutic targets for immunotherapy research. A deeper understanding of immune cell distributions in the TME in hepatocellular carcinoma (HCC) is needed to identify interactions among different immune cell types that might impact the effectiveness of potential immunotherapies. We performed multiplex immunohistochemistry using a tissue microarray of samples from 302 patients with HCC to elucidate the spatial distributions of immune cell subpopulations (CD3<sup>+</sup> , CD4<sup>+</sup> , CD8<sup>+</sup> , CD66b<sup>+</sup> , and CD68<sup>+</sup> ) in HCC and normal liver tissues. We analyzed the associations between different immune subpopulations using P"],"journal":["Cancer science"],"pubmed_title":["The spatial distribution of immune cell subpopulations in hepatocellular carcinoma."],"pmcid":["PMC8819352"],"funding_grant_id":["81472672","2020MHJC06","91942313","18410721900","2018ZX10302207"],"pubmed_authors":["Wang PC","Yu SY","Su S","Li J","Huang XW","Hu ZQ","Ren N","Mao L","Zhou SL"],"additional_accession":[]},"is_claimable":false,"name":"The spatial distribution of immune cell subpopulations in hepatocellular carcinoma.","description":"Infiltrating immune cells in the tumor microenvironment (TME) influence tumor progression and patient prognosis, making them attractive therapeutic targets for immunotherapy research. A deeper understanding of immune cell distributions in the TME in hepatocellular carcinoma (HCC) is needed to identify interactions among different immune cell types that might impact the effectiveness of potential immunotherapies. We performed multiplex immunohistochemistry using a tissue microarray of samples from 302 patients with HCC to elucidate the spatial distributions of immune cell subpopulations (CD3<sup>+</sup> , CD4<sup>+</sup> , CD8<sup>+</sup> , CD66b<sup>+</sup> , and CD68<sup>+</sup> ) in HCC and normal liver tissues. We analyzed the associations between different immune subpopulations using P","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Feb","modification":"2025-04-26T12:25:15.894Z","creation":"2025-04-06T13:55:33.193Z"},"accession":"S-EPMC8819352","cross_references":{"pubmed":["34779545"],"doi":["10.1111/cas.15202"]}}