biostudies-literatureDhakal PNational Institute of General Medical SciencesNIGMS NIH HHS311-321https://www.ebi.ac.uk/biostudies/studies/S-EPMC8819600biostudies-literatureUnknown18(3)<b>Background:</b> We used the Therapy Preference Scale, a 30-item questionnaire, to determine cancer treatment preferences of adults with cancer. <b>Methods:</b> We used Wilcoxon's rank sum test and Fisher's exact test to compare the preferences of younger (<60 years) versus older adults (≥60 years). <b>Results:</b> While 56% of patients would accept treatment offering increased life expectancy at an expense of short-term side effects, 75% preferred maintenance of cognition, functional ability and quality of life to quantity of days. Oral instead of intravenous treatment (p = 0.003), shorter hospital stay (p = 0.03), preservation of cognitive function (p = 0.01) and avoidance of pain (p = 0.02) were more important to older patients compared with younger patients. <b>Conclusion:</b> Many patients prioritized maintenance of cognition, functional ability and quality of life; older patients valued oral treatment, shorter hospital stay, preservation of cognitive function and avoidance of pain.Future oncology (London, England)Preferences of adults with cancer for systemic cancer treatment: do preferences differ based on age?PMC8819600GM115458U54 GM115458Wichman CSPozehl BBociek RGBhatt VRDhakal PVose JWeaver MFisher ALfalsePreferences of adults with cancer for systemic cancer treatment: do preferences differ based on age?<b>Background:</b> We used the Therapy Preference Scale, a 30-item questionnaire, to determine cancer treatment preferences of adults with cancer. <b>Methods:</b> We used Wilcoxon's rank sum test and Fisher's exact test to compare the preferences of younger (<60 years) versus older adults (≥60 years). <b>Results:</b> While 56% of patients would accept treatment offering increased life expectancy at an expense of short-term side effects, 75% preferred maintenance of cognition, functional ability and quality of life to quantity of days. Oral instead of intravenous treatment (p = 0.003), shorter hospital stay (p = 0.03), preservation of cognitive function (p = 0.01) and avoidance of pain (p = 0.02) were more important to older patients compared with younger patients. <b>Conclusion:</b> Many patients prioritized maintenance of cognition, functional ability and quality of life; older patients valued oral treatment, shorter hospital stay, preservation of cognitive function and avoidance of pain.2022-01-01T00:00:00Z2022 Jan2025-04-19T18:08:00.649Z2025-04-19T18:08:00.649ZS-EPMC88196003476168110.2217/fon-2021-0260