biostudies-literatureUnknown38(1)Leon SJ<b>Background:</b> Opioid analgesics are among the most commonly prescribed medications, but questions remain regarding their impact on the day-to-day functioning of patients including driving. We set out to perform a systematic review on the risk of motor vehicle collision (MVC) associated with prescription opioid exposure. <b>Method:</b> We searched Medline, PubMed, EMBASE, Scopus, and TRID from January 1990 to August 31, 2021 for primary studies assessing prescribed opioid use and MVCs. <b>Results:</b> We identified 14 observational studies that met inclusion criteria. Among those, 8 studies found an increased risk of MVC among those participants who had a concomitant opioid prescription at the time of the MVC and 3 found no significant increase of culpability of fatal MVC. The 3 studieThe Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians54-62https://www.ebi.ac.uk/biostudies/studies/S-EPMC8820048biostudies-literatureOpioids and the Risk of Motor Vehicle Collision: A Systematic Review.PMC8820048Hougen IKomenda PTrachtenberg ARigatto CFerguson TAskin NLeon SJBriscoe DAhmed MTangri NWhitlock RfalseOpioids and the Risk of Motor Vehicle Collision: A Systematic Review.<b>Background:</b> Opioid analgesics are among the most commonly prescribed medications, but questions remain regarding their impact on the day-to-day functioning of patients including driving. We set out to perform a systematic review on the risk of motor vehicle collision (MVC) associated with prescription opioid exposure. <b>Method:</b> We searched Medline, PubMed, EMBASE, Scopus, and TRID from January 1990 to August 31, 2021 for primary studies assessing prescribed opioid use and MVCs. <b>Results:</b> We identified 14 observational studies that met inclusion criteria. Among those, 8 studies found an increased risk of MVC among those participants who had a concomitant opioid prescription at the time of the MVC and 3 found no significant increase of culpability of fatal MVC. The 3 studie2022-01-01T00:00:00Z2022 Feb2025-04-04T12:10:31.962Z2025-04-04T12:10:31.962ZS-EPMC88200483514172810.1177/87551225211059926