biostudies-literatureVose AKNICHD NIH HHSMedical Research and Materiel CommandCongressionally Directed Medical Research ProgramsSaskatchewan Health Research FoundationLungs for Life FoundationWings for Life Spinal Cord Research FoundationEvelyn F Mcknight Brain Research FoundationNHLBI NIH HHSU.S. Department of DefenseNational Institutes of HealthUS Army Medical Research and Materiel CommandCraig H. Neilsen Foundation113891https://www.ebi.ac.uk/biostudies/studies/S-EPMC8820239biostudies-literatureUnknown347We review progress towards greater mechanistic understanding and clinical translation of a strategy to improve respiratory and non-respiratory motor function in people with neuromuscular disorders, therapeutic acute intermittent hypoxia (tAIH). In 2016 and 2020, workshops to create and update a "road map to clinical translation" were held to help guide future research and development of tAIH to restore movement in people living with chronic, incomplete spinal cord injuries. After briefly discussing the pioneering, non-targeted basic research inspiring this novel therapeutic approach, we then summarize workshop recommendations, emphasizing critical knowledge gaps, priorities for future research effort, and steps needed to accelerate progress as we evaluate the potential of tAIH for routine Experimental neurologyTherapeutic acute intermittent hypoxia: A translational roadmap for spinal cord injury and neuromuscular disease.PMC8820239SCI130298R01HD081274WFL-US-026R01HL147554R01 HL147554R01 HD081274W81XWH-15-2-0045Welch JFFox EJMitchell GSTrumbower RDNair JDale EAVose AKMuir GDfalseTherapeutic acute intermittent hypoxia: A translational roadmap for spinal cord injury and neuromuscular disease.We review progress towards greater mechanistic understanding and clinical translation of a strategy to improve respiratory and non-respiratory motor function in people with neuromuscular disorders, therapeutic acute intermittent hypoxia (tAIH). In 2016 and 2020, workshops to create and update a "road map to clinical translation" were held to help guide future research and development of tAIH to restore movement in people living with chronic, incomplete spinal cord injuries. After briefly discussing the pioneering, non-targeted basic research inspiring this novel therapeutic approach, we then summarize workshop recommendations, emphasizing critical knowledge gaps, priorities for future research effort, and steps needed to accelerate progress as we evaluate the potential of tAIH for routine 2022-01-01T00:00:00Z2022 Jan2025-04-22T10:10:48.572Z2025-04-05T23:26:35.915ZS-EPMC88202393463780210.1016/j.expneurol.2021.113891