{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Deng AP"],"pubmed_abstract":["Sulfur Angelicae Dahuricae Radix (Baizhi) is a common medicinal herb in Asian countries. A practical protocol combining metabolomics, pharmacology, and cytotoxicity was developed to comprehensively evaluate the influence of sulfur-fumigation on the quality of Baizhi. Furocoumarins could be transformed into sulfur-containing compounds during the sulfuring process, among which <b>1</b> and <b>3</b> were purified with relatively high abundance and identified as 3,4-dihydrobyakangelicin-4-sulfonic acid and (4<i>R</i>,12<i>S</i>)-3,4-dihydrooxypeucedanin hydrate-4-sulfonic acid (OXH-S), respectively. OXH-S was found to be an addition product of sulfite and oxypeucedanin hydrate (OXH-N). Then, the cytotoxicity and anti-inflammatory activity of OXH-N, OXH-S, and water extracts of sulfured (extrac"],"journal":["Frontiers in pharmacology"],"pagination":["799504"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8822044"],"repository":["biostudies-literature"],"pubmed_title":["Practical Protocol for Comprehensively Evaluating Sulfur-Fumigation of Baizhi Based on Metabolomics, Pharmacology, and Cytotoxicity."],"pmcid":["PMC8822044"],"pubmed_authors":["Zhou L","Zhang WJ","Kang LP","Lyu CG","Zhan ZL","Wang S","Guo LP","Huang LQ","Deng AP","Nan TG","Kang CZ","Wang HY"],"additional_accession":[]},"is_claimable":false,"name":"Practical Protocol for Comprehensively Evaluating Sulfur-Fumigation of Baizhi Based on Metabolomics, Pharmacology, and Cytotoxicity.","description":"Sulfur Angelicae Dahuricae Radix (Baizhi) is a common medicinal herb in Asian countries. A practical protocol combining metabolomics, pharmacology, and cytotoxicity was developed to comprehensively evaluate the influence of sulfur-fumigation on the quality of Baizhi. Furocoumarins could be transformed into sulfur-containing compounds during the sulfuring process, among which <b>1</b> and <b>3</b> were purified with relatively high abundance and identified as 3,4-dihydrobyakangelicin-4-sulfonic acid and (4<i>R</i>,12<i>S</i>)-3,4-dihydrooxypeucedanin hydrate-4-sulfonic acid (OXH-S), respectively. OXH-S was found to be an addition product of sulfite and oxypeucedanin hydrate (OXH-N). Then, the cytotoxicity and anti-inflammatory activity of OXH-N, OXH-S, and water extracts of sulfured (extrac","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2025-04-26T03:50:18.252Z","creation":"2025-04-06T10:58:20.187Z"},"accession":"S-EPMC8822044","cross_references":{"pubmed":["35145404"],"doi":["10.3389/fphar.2021.799504"]}}