biostudies-literatureJuul SENINDS NIH HHSe2146404https://www.ebi.ac.uk/biostudies/studies/S-EPMC8822378biostudies-literatureUnknown5(2)<h4>Importance</h4>Understanding why and how extremely preterm infants die is important for practitioners caring for these infants.<h4>Objective</h4>To examine risk factors, causes, timing, and circumstances of death in a modern cohort of extremely preterm infants.<h4>Design, setting, and participants</h4>A retrospective cohort review of infants enrolled in the Preterm Erythropoietin Neuroprotection Trial between December 13, 2013, and September 26, 2016, was conducted. A total of 941 infants born between 24 0/7 and 27 6/7 weeks of gestation enrolled at 19 US sites comprising 30 neonatal intensive care units were included. Data analysis was performed from October 16, 2020, to December 1, 2021.<h4>Main outcomes and measures</h4>Risk factors, proximal causes, timing, and circumstances of in-JAMA network openDeaths in a Modern Cohort of Extremely Preterm Infants From the Preterm Erythropoietin Neuroprotection Trial.PMC8822378U01 NS077953U01 NS077955Talele NBazacliu CKuan EDaly RPatel PAhmad KAVu PTTalbot MBarnhart LRau CGogcu SWright JBeauman SGalvis EMHanson MSchau MJuul SEPerez JEPENUT ConsortiumSerize AEFranco Mora AKaletka BGilmore MMFisher MDrake TOsborne MPPenny SMcKay VWood TRNefcy CThomas BMason MMcGrath KDavern BGeorgieff MLee KSchaefer SHeagerty PJMartin CRSaurabhkumar PChavez Valdez RCole LYoder BBird KGeorge TElhassan NKase JSKonodi MAWadhawan RWegner RECheck JKohlleppel KBoles TMayock DEdeRegnier RAParkinson CWassenaar JLanier KO'Shea MLampland ASikes NHedrick PPearson DDrummond MOsterholm ENorthington FNason JO'Reilly DGinder ARao RWyatt ABurnett JClarke MGuy ARussow AObregon EWeaver Lewis KMulrooney NBaserga MFeltner JBLowe JBombino SEricksen JGregorich BDowney LCOhls RKReich BComstock BACourtney SECurry KNikirk SLoy EMartinez DLong CWorwa CRichter TBendel-Stenzel EGonzales SWarden KJordan JWalden DSilvia AFlynn VBackstrom Lacy CPorta NZiyeh TVijayamadhavan VKFahim NEsposito IWeiss MHarrison HPerez KSrinivasan NBallard RLoertscher MDiaz-Barbosa MHauge SGiblin CRobinson TMcConnell JPuia-Dumitrescu MFrantz IDBerkelhamer SWidness JClopp BKhan JLaGamma EFHartman ABell SKathen CMulkey SOtt DBrown TfalseDeaths in a Modern Cohort of Extremely Preterm Infants From the Preterm Erythropoietin Neuroprotection Trial.<h4>Importance</h4>Understanding why and how extremely preterm infants die is important for practitioners caring for these infants.<h4>Objective</h4>To examine risk factors, causes, timing, and circumstances of death in a modern cohort of extremely preterm infants.<h4>Design, setting, and participants</h4>A retrospective cohort review of infants enrolled in the Preterm Erythropoietin Neuroprotection Trial between December 13, 2013, and September 26, 2016, was conducted. A total of 941 infants born between 24 0/7 and 27 6/7 weeks of gestation enrolled at 19 US sites comprising 30 neonatal intensive care units were included. Data analysis was performed from October 16, 2020, to December 1, 2021.<h4>Main outcomes and measures</h4>Risk factors, proximal causes, timing, and circumstances of in-2022-01-01T00:00:00Z2022 Feb2026-03-27T16:44:41.874Z2025-04-04T21:32:24.808ZS-EPMC88223783512959610.1001/jamanetworkopen.2021.46404