biostudies-literatureMarinac CRSU2CNCI NIH HHSAmerican Society of HematologyNCI NIH NCINCI NIH479-485https://www.ebi.ac.uk/biostudies/studies/S-EPMC8825752biostudies-literatureUnknown31(2)<h4>Background</h4>Inflammation is important in multiple myeloma pathogenesis, and regular aspirin use has been shown to confer a reduced risk of multiple myeloma. The influence of aspirin on survival after multiple myeloma diagnosis is unknown.<h4>Methods</h4>We identified 436 men and women diagnosed with multiple myeloma between 1980 and 2016 in the Health Professionals Follow-up Study and the Nurses' Health Study who reported aspirin intake biennially on follow-up questionnaires. Using multivariable Cox proportional hazards regression models, we estimated HRs and 95% confidence intervals (CI) associated with the effect of aspirin use on multiple myeloma-specific and overall mortality.<h4>Results</h4>Compared with nonusers, participants who used aspirin after diagnosis had a multivariablCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive OncologyRegular Aspirin Use and Mortality in Patients with Multiple Myeloma.PMC8825752PF-17–231–01-CCEK07 CA115687F32 CA220859R03 CA204825U01 CA167552P01 CA87969P01 CA087969AACR-DT-28-18R21 CA198239R01 CA127435K22 CA251648UM1 CA186107Ghobrial IMLee DHColditz GAMarinac CRRosner BBirmann BMBustoros MRebbeck TRfalseRegular Aspirin Use and Mortality in Patients with Multiple Myeloma.<h4>Background</h4>Inflammation is important in multiple myeloma pathogenesis, and regular aspirin use has been shown to confer a reduced risk of multiple myeloma. The influence of aspirin on survival after multiple myeloma diagnosis is unknown.<h4>Methods</h4>We identified 436 men and women diagnosed with multiple myeloma between 1980 and 2016 in the Health Professionals Follow-up Study and the Nurses' Health Study who reported aspirin intake biennially on follow-up questionnaires. Using multivariable Cox proportional hazards regression models, we estimated HRs and 95% confidence intervals (CI) associated with the effect of aspirin use on multiple myeloma-specific and overall mortality.<h4>Results</h4>Compared with nonusers, participants who used aspirin after diagnosis had a multivariabl2022-01-01T00:00:00Z2022 Feb2025-04-04T19:40:34.867Z2025-04-04T19:40:34.867ZS-EPMC88257523486220810.1158/1055-9965.epi-21-094610.1158/1055-9965.EPI-21-0946